血清总胆固醇对晚期结肠癌患者预后的影响  

Serum total cholesterol on prognosis of advanced colon cancer

作　　者：苑小星 杨海芳[1] YUAN Xiaoxing;YANG Haifang(Department of Oncology,Beijing Pinggu Hospital,Beijing 101200,China)

机构地区：[1]北京市平谷区医院血液肿瘤科,北京101200

出　　处：《癌症进展》2020年第16期1660-1663,共4页Oncology Progress

摘　　要：目的探讨晚期结肠癌患者的总胆固醇水平与临床特征和预后的关系。方法回顾性分析98例晚期结肠癌患者的临床资料,分析结肠癌自然病程中总胆固醇增高的发生率及其与患者临床特征和预后的关系。结果98例患者中,总胆固醇增高组患者62例(63.3%),总胆固醇为5.72(4.98,6.52)mmol/L。总胆固醇增高组与正常组患者分化程度及肝转移情况比较,差异均有统计学意义(P﹤0.01)。总胆固醇增高组的客观缓解率为38.7%(24/62),明显低于总胆固醇正常组的66.7%(24/36),差异有统计学意义(P﹤0.01)。总胆固醇增高组患者的中位生存时间为24个月(95%CI:20.915~27.085),明显短于总胆固醇正常组患者的37个月(95%CI:31.688~42.312),差异有统计学意义(P﹤0.01)。Cox多因素分析结果显示,分化程度、肝转移、血清总胆固醇均为结肠癌患者预后的独立影响因素(P﹤0.05)。结论晚期结肠癌患者自然病程中总胆固醇增高的发生率高;总胆固醇增高与肿瘤细胞分化程度、肝转移及客观缓解率有关;血清总胆固醇为结肠癌患者预后的独立影响因素。Objective To investigate the relationship of serum total cholesterol with clinical features and prognosis of patients with advanced colon cancer.Method The clinical data of 98 patients with advanced colon cancer were retrospectively analyzed for the incidence of hypercholesterolemia and the relationship with clinical features and prognosis during the natural course of colon cancer.Result There were 62 cases(62/98,63.3%)of hypercholesterolemia[median 5.72(4.98,6.52)mmol/L]patients,with significant differences for the differentiation and liver metastasis than those patients with normal cholesterol(P<0.01).There were significant lower objective response rate[38.7%(24/62)vs 66.7%(24/36),P<0.01]and shorter median survival[24 months(95%CI:20.915-27.085)vs 37 months(95%CI:31.688-42.312),P<0.01]compared with patients of normal cholesterol.The results of multivariable Cox analysis showed that the differentiation,liver metastasis,incidence of hypercholesterolemia were independent factors of prognosis of patients with colon cancer(P<0.05).Conclusion The incidence of hypercholesterolemia is high during the natural course of advanced colon cancer.The incidence of hypercholesterolemia is correlated with differentiation of tumor cells,liver metastasis and objective response rate.Incidence of hypercholesterolemiais the independent prognosis factor of patients with colon cancer.

关 键 词：结肠癌 总胆固醇 预后 

分 类 号：R735.3[医药卫生—肿瘤]