嗜酸性粒细胞趋化因子-1在肺癌合并哮喘患者气道上皮细胞中的表达情况及对症处理研究  

Expression of eotaxin-1 in airway epithelial cells of lung cancer patients with asthma and symptomatic treatment

作　　者：韩月玲[1] 方宇[1] 罗永刚[1] 刘文慧 HAN Yueling;FANG Yu;LUO Yonggang;LIU Wenhui(Comprehensive ICU,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,He’nan,China)

机构地区：[1]郑州大学第一附属医院综合ICU,郑州450052

出　　处：《癌症进展》2020年第16期1712-1715,1719,共5页Oncology Progress

基　　金：河南省科技攻关计划项目(15A320079)。

摘　　要：目的探讨嗜酸性粒细胞趋化因子-1(Eot-1)在肺癌合并哮喘患者气道上皮细胞中的表达情况及施行针对性的呼吸道对症处理的干预效果。方法选取252例肺癌合并哮喘患者,其中重度哮喘和轻中度哮喘患者各126例。根据随机数字表法将126例肺癌合并重度哮喘患者分为对照组和观察组,各63例。对照组接受常规护理,观察组在常规护理的基础上接受有针对性的负性心理护理干预。比较肺癌合并重度哮喘和肺癌合并轻中度哮喘患者气道上皮细胞中Eot-1的表达情况;比较观察组和对照组患者护理后第6天的排痰量、痰液黏稠度、呼吸困难评分、急性生理学及慢性健康状况评分系统Ⅱ(APACHEⅡ)评分以及肺部感染的发生率。结果肺癌合并重度哮喘患者气道上皮细胞中Eot-1蛋白和基因的相对表达量均明显高于肺癌合并轻中度哮喘患者(P﹤0.01)。护理后第6天,两组患者的排痰量均高于本组护理前(P﹤0.05),且观察组患者的排痰量明显多于对照组患者(P﹤0.01)。护理后第6天,观察组患者Ⅰ度痰液黏稠度的发生率高于对照组,Ⅲ度痰液黏稠度的发生率低于对照组(P﹤0.05)。护理后,观察组患者的呼吸困难、APACHEⅡ评分、肺部感染的发生率均明显低于对照组患者(P﹤0.01)。结论Eot-1在肺癌合并哮喘患者的气道上皮细胞中呈高表达,针对性的呼吸道护理可明显改善患者呼吸困难的症状,且能够降低肺部感染的发生率,值得临床推广。Objective To investigate the expression of eotaxin-1(Eot-1) in airway epithelial cells of lung cancer patients with asthma and the intervention effect of respiratory symptomatic treatment. Method A total of 252 lung cancer patients with asthma were selected, including 126 patients with severe asthma and 126 patients with mild and moderate asthma. 126 lung cancer patients with severe asthma were divided into the control group(n=126) and observation gorup(n=126) by random numbers, treated with routine nursing and additional negative emotion nursing on the basis of routine nursing, respectively. Comparing the expression of Eot-1 in airway epithelial cells of patients with severe asthma and those with mild and moderate asthma. In the observation gorup and control group, the 6 th-day expectoration drainage, sputum viscosity, dyspnea scores, acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) scores and the pulmonary infection rate were compared. Result The expression of Eot-1 protein and gene in airway epithelial cells of patients with severe asthma was significantly higher than that of patients with mild to moderate asthma(P<0.01). There was higher expectoration drainage volume on the 6th day after nursing than that before nursing(P<0.05) and higher in the observation group than that in the control group(P<0.01). There were higher rates of 1 degree sputum viscosity and lower rates of 3 degree sputum viscosity in the observation group than those in the control group 6 days after nursing(P<0.05). The dyspnea scores, APACHE Ⅱ scores and the pulmonary infection rate were significantly lower than those in the control group(P<0.01). Conclusion Eot-1 is highly expressed in airway epithelial cells of lung cancer patients with asthma. Targeted respiratory care can significantly improve the symptoms of dyspnea and reduce lung infection, which is worthy of clinical promotion.

关 键 词：肺癌 哮喘 气道上皮细胞 嗜酸性粒细胞 负性心理 

分 类 号：R734.2[医药卫生—肿瘤]