Neuronal Activity in the Cerebellum During the Sleep-Wakefulness Transition in Mice  

作　　者：Li-Bin Zhang Jie Zhang Meng-Jia Sun Hao Chen Jie Yan Fen-Lan Luo Zhong-Xiang Yao Ya-Min Wu Bo Hu 

机构地区：[1]Department of Physiology,College of Basic Medical Sciences,Army Medical University,Chongqing 400038,China [2]State Key Laboratory of Trauma,Bums and Combined Injury,Daping Hospital/Research Institute of Surgery,Army Medical University,Chongqing 400042,China [3]Squadron 10,Battalion 3,College of Basic Medical Sciences,Army Medical University,Chongqing 400038,China

出　　处：《Neuroscience Bulletin》2020年第8期919-931,共13页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China (81671315);the Natural Science Foundation of Chongqing Municipality (cstc2019jcyj-msxmX0424);the Frontier Interdisciplinary Project of the College of Basic Sciences,Army Medical University,China (2018JCQY01);the National Training Program of Innovation and Entrepreneurship for Undergraduates,China (201990035020)。

摘　　要：Cerebellar malfunction can lead to sleep disturbance such as excessive daytime sleepiness,suggesting that the cerebellum may be involved in regulating sleep and/or wakefulness.However,understanding the features of cerebellar regulation in sleep and wakefulness states requires a detailed characterization of neuronal activity within this area.By performing multiple-unit recordings in mice,we showed that Purkinje cells(PCs)in the cerebellar cortex exhibited increased firing activity prior to the transition from sleep to wakefulness.Notably,the increased PC activity resulted from the inputs of lowfrequency non-PC units in the cerebellar cortex.Moreover,the increased PC activity was accompanied by decreased activity in neurons of the deep cerebellar nuclei at the nonrapid eye-movement sleep-wakefulness transition.Our results provide in vivo electrophysiological evidence that the cerebellum has the potential to actively regulate the sleep-wakefulness transition.

关 键 词：SLEEP WAKEFULNESS Multiple-unit recording Purkinje cell Deep cerebellar nuclei 

分 类 号：R338.63[医药卫生—人体生理学]