C反应蛋白与清蛋白比值对重症急性胰腺炎预后的预测价值  

The predictive value of C-reactive protein to albumin ratio for the prognosis of severe acute pancreatitis

作　　者：李盛[1] 焦志勇[1] 钟燕明 饶佩斯 陈斌[1] 朱蔓然[1] 秦永军 LI Sheng;JIAO Zhiyong;ZHONG Yanming;RAO Peisi;CHEN Bin;ZHU Manran;QIN Yongjun(Department of Gastroenterology,Yue Bei People's Hospital,Guangdong,Shaoguan 512026,China)

机构地区：[1]粤北人民医院消化内科,广东韶关512026

出　　处：《中国医药科学》2020年第15期209-212,共4页China Medicine And Pharmacy

基　　金：广东省韶关市卫生健康科研项目(Y20209)。

摘　　要：目的探讨C反应蛋白与清蛋白比值(CAR)对重症急性胰腺炎预后的预测价值。方法选取2017年11月~2019年11月在我院住院的105例重症急性胰腺炎患者进行回顾性分析,依据临床预后分为存活组91例及死亡组14例。入院24h内采血送检,比较两组的C反应蛋白(CRP)、清蛋白(ALB)水平及CAR。结果重症急性胰腺炎存活组和死亡组年龄、性别、ALB水平差异均无统计学意义(P>0.05)。存活组的CRP和CAR低于死亡组,差异有统计学意义(P<0.05)。二元Logistic回归分析结果提示CRP(OR=1.024,95%CI:1.002~1.046)和CAR(OR=1.785,95%CI:1.149~2.773)是重症急性胰腺炎预后不良的独立危险因素。ROC曲线结果提示CAR曲线下面积(AUC)最大(AUC=0.730,P=0.06),当取最佳界值为3.95时,其对应的灵敏性和特异性分别为57.1%和65.9%。结论入院24h内CAR是重症急性胰腺炎预后的独立危险因素,对重症急性胰腺炎的预后具有较好的预测效能。Objective To investigate the predictive value of C-reactive protein to albumin ratio(CAR)for the prognosis of severe acute pancreatitis(SAP).Methods 105 patients with SAP hospitalized in our hospital from November 2017 to November 2019 were selected for retrospective analysis.According to clinical prognosis,they were divided into the survival group(n=91)and the death group(n=14).Blood samples were collected within 24 hours of admission to the hospital for inspection,and the level of C-reactive protein(CRP)and albumin(ALB)and the CAR in the two groups were compared.Results There was no statistically significant difference in age,sex and ALB level between the survival group and the death group of SAP(P>0.05).The CRP and CAR of the survival group were lower than those of the death group(P<0.05).The results of binary Logistic regression analysis revealed that the CRP(OR=1.024,95%CI:1.002-1.046)and CAR(OR=1.785,95%CI:1.149-2.773)were independent risk factors for poor prognosis of SAP.ROC curve results showed that when the area under curve(AUC)of the CAR was the largest(AUC=0.730,P=0.06)and the optimal cut-off point was 3.95,the corresponding sensitivity and specificity were respectively 57.1%and 65.9%.Conclusion CAR is an independent risk factor for the prognosis of SAP within 24 hours of admission to a hospital,and it has good prediction efficiency for the prognosis of SAP.

关 键 词：C反应蛋白与清蛋白比值 重症急性胰腺炎 预后 预测 

分 类 号：R576[医药卫生—消化系统]