紫杉醇、卡铂化疗联合放疗对子宫内膜癌患者原癌基因及抑癌基因的影响  

Effects of Paclitaxel and Carboplatin Chemotherapy Combined with Radiotherapy on Proto-oncogenes and Tumor Suppressor Genes in Patients with Endometrial Cancer

作　　者：郭宝宁 GUO Bao-ning(Shangqiu Municipal Hospital Oncology Department,Shangqiu Henan 476100,China)

机构地区：[1]商丘市立医院肿瘤科,河南商丘476100

出　　处：《药品评价》2020年第12期29-31,39,共4页Drug Evaluation

摘　　要：目的:探讨紫杉醇、卡铂化疗联合放疗对子宫内膜癌患者原癌基因及抑癌基因的影响。方法:回顾性分析我院妇产科2017年1月—2020年3月收治的60例子宫内膜癌患者临床资料,将采用单纯常规化疗方案的患者纳入对照组(28例),将采用紫杉醇与卡铂化疗联合放疗方案的患者纳入观察组(32例)。比较两组患者治疗前、治疗2个疗程后的免疫功能指标、原癌基因及抑癌基因变化情况以及治疗过程中不良反应发生情况。结果:两组治疗前各免疫功能指标比较,差异无统计学意义(P>0.05);治疗2个疗程后,两组分化簇4(CD4^+)、分化簇8(CD8^+)及CD4^+/CD8^+指标均上升,且观察组上升幅度较大,差异有统计学意义(P<0.05)。两组治疗前各原癌基因表达量、各抑癌基因表达量对比,差异无统计学意义(P>0.05);治疗2个疗程后,两组C-myc、C-erbB2及K-ras表达量均下降,且观察组下降幅度较大,差异有统计学意义(P<0.05);两组P53、P16及人第10号染色体缺失的磷酸酶及张力蛋白同源的基因(PTEN)表达量均上升,且观察组上升幅度较大,差异有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:子宫内膜癌患者采用紫杉醇+卡铂化疗联合放疗效果确切,可有效增强免疫功能,改善原癌基因与抑癌基因表达情况,减少不良反应的发生,值得临床推广应用。Objective:To investigate the effect of paclitaxel and carboplatin chemotherapy combined with radiotherapy on proto-oncogenes and tumor suppressor genes in patients with endometrial cancer.Methods:Retrospectively analyzed the clinical data of 60 patients with endometrial cancer who were received by the Obstetrics and Gynecology Department of our hospital from January 2017 to March 2020.Patients with simple conventional chemotherapy were included in the control group (28 cases),and patients with paclitaxel and carboplatin combined with radiotherapy were included in the observation group (32 cases).Compared the immune function indexes,changes of proto-oncogenes and tumor suppressor genes,and the incidence of adverse reactions during treatment between the two groups of patients before and after two courses of treatment.Results:There was no statistically significant difference in the immune function indexes between the two groups before treatment (P>0.05);after two courses of treatment,the differentiation cluster 4 (CD4^+),differentiation cluster 8 (CD8^+) and CD4^+/CD8^+ indexes of both groups were increased,and the increase in the observation group was larger,the difference was statistically significant (P<0.05).There was no significant difference in the expression of proto-oncogenes and tumor suppressor genes between the two groups before treatment (P>0.05);after two courses of treatment,the expression amount of C-myc,C-erbB2 and K-ras in the two groups was decreased,and the observation group had a larger decrease,the difference was statistically significant (P<0.05);the P53,P16 and phosphatase which were deleted from human chromosome 10th and the expression of PTEN homologous genes (PTEN) were all increased,and the increase in the observation group was larger,the difference was statistically significant (P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant (P<0.05).Conclusion:The combination of paclitaxel and c

关 键 词：子宫内膜癌 紫杉醇 卡铂 免疫功能 原癌基因 抑癌基因 

分 类 号：R737.33[医药卫生—肿瘤]