普拉洛芬与氟米龙分别联合玻璃酸钠治疗中重度干眼的对比研究  

A Comparative Study of Pranoprofen and Fluorometholone Combined with Sodium Hyaluronate in the Treatment of Moderate to Severe Dry Eyes

作　　者：陈彦霓 李文涛 廖锐[1] CHEN Yanni;LI Wentao;LIAO Rui(Huizhou Third People’s Hospital,Huizhou 516000,China;不详)

机构地区：[1]广东省惠州市第三人民医院,广东惠州516000

出　　处：《中国医学创新》2020年第25期30-34,共5页Medical Innovation of China

摘　　要：目的:探讨普拉洛芬与氟米龙分别联合玻璃酸钠治疗中重度干眼的效果。方法:选取2016年8月-2019年11月本院收治的120例(237眼)中重度干眼患者为研究对象。按照随机数字表法分为研究组60例(118眼)与对照组60例(119眼)。对照组采用氟米龙联合玻璃酸钠治疗,研究组采用普拉洛芬联合玻璃酸钠治疗。比较治疗前及治疗4周后两组患者眼部症状[眼表疾病指数量表(OSDI)、泪河高度、泪膜破裂时间(BUT)],生活质量[视功能损害眼病患者生活质量量表(SQOL-DVI)],眼压及结膜充血程度评分。比较治疗4周后两组的治疗效果及治疗4周内两组药物不良反应发生情况。结果:治疗4周后,研究组治疗总有效率为91.53%,明显高于对照组的68.07%,差异有统计学意义(P<0.05)。治疗4周后,两组患者眼压、结膜充血程度评分及OSDI评分均较治疗前显著降低,且研究组上述指标均明显低于对照组,差异均有统计学意义(P<0.05)。治疗4周后,两组BUT均较治疗前显著延长,且研究组时间长于对照组,差异均有统计学意义(P<0.05)。治疗4周后,两组泪河高度、SQOL-DVI各维度评分均较治疗前显著升高,且研究组上述指标均明显高于对照组,差异均有统计学意义(P<0.05)。治疗4周后,两组患者眼压增高、异物感、眼睑充血发生率比较,差异均无统计学意义(P>0.05)。结论:普拉洛芬联合玻璃酸钠治疗中重度干眼患者可取得更好治疗效果,改善眼部症状、眼压及结膜充血程度,提高患者生活质量,保证用药安全性。Objective:To investigate the effects of Pranoprofen and Fluorometholone combined with Sodium Hyaluronate in the treatment of moderate to severe dry eyes.Method:A total of 120 patients(237 eyes)with moderate to severe dry eyes admitted to our hospital from August 2016 to November 2019 were selected as study subjects.According to the random number table method,60 cases(118 eyes)in study group and 60 cases(119 eyes)in control group were divided.The control group was treated with Fluorometholone combined with Sodium Hyaluronate,while the study group was treated with Pranoprofen combined with Sodium Hyaluronate.Before treatment and 4 weeks after treatment,the ocular symptoms[OSDI,tear river height,tear film break time(BUT)],quality of life(SQOL-DVI),intraocular pressure and conjunctival congestion scores were compared between the two groups.The therapeutic effect of the two groups after 4 weeks of treatment and the incidence of adverse drug reactions within 4 weeks were compared.Result:After 4 weeks of treatment,the total effective rate of the study group was 91.53%,significantly higher than 68.07%of the control group,with statistically significant difference(P<0.05).After 4 weeks of treatment,intraocular pressure,conjunctival congestion degree scores and OSDI scores of patients in both groups were significantly lower than those before treatment,and the above indicators in the study group were significantly lower than those in the control group,with statistically significant differences(P<0.05).After 4 weeks of treatment,BUT in both groups were significantly longer than those of before treatment,and the time in the study group was longer than that in the control group,the difference were statistically significant(P<0.05).After 4 weeks of treatment,the height of lacrial river and SQOL-DVI scores in all dimensions of the two groups were significantly higher than those of before treatment,and the above indexes in the study group were significantly higher than those in the control group,with statistically significant diff

关 键 词：普拉洛芬 氟米龙 玻璃酸钠 中重度干眼 

分 类 号：R777.34[医药卫生—眼科]