血管内皮中KLF2的表观遗传修饰调控  

Epigenetic modification of KLF2 in vascular endothelium

作　　者：姚裕锋 黄绍刚 林泽帆 陈奕钿 李枞森 陈嘉莹[1] 曾小耘 Yao Yu-feng;Huang Shao-gang;Lin Ze-fan;Chen Yi-tian;Li Cong-sen;Chen Jia-ying;Zeng Xiao-yun(Department of Clinical Medicine(Undergraduate Student),Shantou University Medical College,Shantou 515041,Guangdong,China;Department of Chemistry,Shantou University Medical College,Shantou 515041,Guangdong,China)

机构地区：[1]汕头大学医学院,广东汕头515041 [2]汕头大学医学院化学教研室,广东汕头515041

出　　处：《四川生理科学杂志》2020年第3期357-361,329,共6页Sichuan Journal of Physiological Sciences

基　　金：2019年汕头市第一批、第二批医疗卫生科技计划项目(编号:413690 07);广东大学生科技创新培育专项(编号:pdjh2019b0188);汕头大学大学生创新创业训练计划项目(编号:201910560129)。

摘　　要：Krüppel样转录因子2(Krüppel-like transcription factor2,KLF2)是Krüppel样转录因子家族中的成员之一,通过多种机制保护血管内皮。血流动力学、炎症反应、氧化应激等因素可引起KLF2的表观遗传修饰,主要机制为IIa类组蛋白去乙酰化酶和肌细胞增强因子的相互作用及KLF2m RNA和小型非编码RNA microRNA-92a的结合。本文重点阐明了各种因素对KLF2表观遗传修饰的调控,为KLF2在心血管疾病的治疗等临床研究提供思路。As a member of Krüppel-like transcription factor,Krüppel-like transcription factor2(KLF2)protects vascular endothelium via various mechanisms.Its epigenetic modification can be induced by hemodynamics,inflammation and oxidative stress mainly by the interaction between histone deacetylases IIa and myocyte enhancer factor 2 and the combination of KLF2 m RNA with microRNA-92 a.In this review,we focus on the epigenetic modification of KLF2 regulated by multiple factors,which provides a promising strategy for treatment of cardiovascular diseases in clinical researches.

关 键 词：Krüppel样转录因子2 血管内皮细胞 表观遗传 转录调节 

分 类 号：R394[医药卫生—医学遗传学]