突变p53在肿瘤发生过程中的功能研究与进展  

Functional Research and Progress of Mutated p53 in Tumorigenesis

作　　者：谢林峰 向俊蓓 姜欣 XIE Linfeng;XIANG Junbei;JIANG Xin(Sichuan Nursing Vocational College,Chengdu 610100,China;不详)

机构地区：[1]四川护理职业学院,四川成都610100 [2]成都生物制品研究所有限责任公司

出　　处：《中国医学创新》2020年第24期169-172,共4页Medical Innovation of China

基　　金：德阳重点科学技术研究项目(2018SZY072)。

摘　　要：p53基因是重要的抑癌基因之一,具有抑制肿瘤的作用,超过50%的癌症伴有p53基因的突变。p53基因的突变不仅导致其肿瘤抑制功能的失去,同时将促进肿瘤的发生发展,此现象被称为获得性新功能(GOF)。本文将从p53与细胞周期、细胞代谢途径及干扰转录调控等方面综合阐述p53与癌症之间的关系,为癌症的创新治疗及靶向药物的开发提供理论依据。p53 gene is one of the important tumor suppressor genes,which has the effect of inhibiting tumor,more than 50%of cancers have the mutation of p53 gene.The mutated p53 gene not only leads to the loss of tumor suppressive function,but also promotes the tumorigenesis.This is called“Gain of function”(GOF).In this paper,the relationship between p53 and cancer will be discussed from the aspects of p53 and cell cycle,cell metabolic pathway and interference of transcriptional regulation,so as to provide theoretical basis for the innovative treatment of cancer and the development of targeted drugs.

关 键 词：P53 肿瘤发生 细胞代谢途径 细胞周期 

分 类 号：R730.2[医药卫生—肿瘤]