中医药干预神经退行性疾病引起的认知功能障碍的分子机制  

Novel Mechanisms of Some Traditional Chinese Medicine for the Therapy of Neurocognitive Disorders

作　　者：张韬 赵磊[3] 战锐 苑桂红[2] 韩鸿宾[1,2] 崔德华[1,2,3] ZHANG Tao;ZHAO Lei;ZHAN Rui;YUAN Gui-Hong;HAN Hong-Bin;CUI De-Hua(Peking University Third Hospital,Key Laboratory of Magnetic Resonance Imaging and Technique,Beijing 100191,China;School of Medical Technology of Peking University,Beijing 100191,China;School of Basic Medical Sciences of Peking University,Beijing 100191,China)

机构地区：[1]北京大学第三医院磁共振技术与设备重点研究室,北京100191 [2]北京大学医学技术研究院,北京100191 [3]北京大学基础医学院,北京100191

出　　处：《生物化学与生物物理进展》2020年第8期729-742,共14页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(81571044,81471633,61450004,81171015);国家高技术研究发展计划(2016YFC1306302,2016YFC1305903);北京市科学技术委员会“脑科学与类脑研究”专项(Z181100001518004);首都科技领军人才培养工程(Z181100006318003)资助项目.

摘　　要：本文综述了中医药对阿尔茨海默病(Alzheimer’s disease,AD)和帕金森病(Parkinson’s disease,PD)引起的认知功能障碍抗炎作用分子机制的研究进展,并讨论了中医药(如伊桐苷、芒柄花素、和厚朴酚、甘露寡糖二酸和红花类黄酮提取物等)在干预神经退行性疾病中的作用机制,具体包括中医药影响Aβ的生成及聚集、tau磷酸化、肠-脑轴和肠道菌群的调节、自噬功能、小胶质细胞极化、细胞外间隙、神经发生和神经递质传递等.This review summarizes recent progress of the anti-inflammatory effect of traditional Chinese medicine on neurocognitive disorders caused by Alzheimer’s disease(AD)and Parkinson’s disease(PD),and discusses some novel molecular mechanisms of traditional Chinese medicine(such as Xylocoside G,Formononetin,Honokiol,Sodium oligomannate and safflower flavonoid extract),including the regulation on Aβgeneration and aggregation,tau phosphorylation,gut-brain axis and gut microbiota,autophagy,microglia polarization,extracellular space,neurogenesis and neurotransmission,for the treatment of AD and PD related neurocognitive disorders.

关 键 词：阿尔茨海默病 炎症 Β-淀粉样蛋白 TAU蛋白 小胶质细胞极化 细胞外间隙 

分 类 号：R741[医药卫生—神经病学与精神病学] R338[医药卫生—临床医学]