高分子纳米材料用于肿瘤放疗增敏的研究进展  

Research progress on polymer nanomaterials for tumor radiotherapy

作　　者：侯小雪 黄帆[1] 杨丽军 刘鉴峰[1] Hou Xiaoxue;Huang Fan;Yang Lijun;Liu Jianfeng(Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300192,China)

机构地区：[1]中国医学科学院北京协和医学院放射医学研究所,天津市放射医学与分子核医学重点实验室,300192

出　　处：《国际放射医学核医学杂志》2020年第6期381-385,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金(21708048、81722026、51603231);中国医学科学院中央级公益性科研院所基本科研业务费专项(2019-RC-HL-014);中国医学科学院医学与健康科技创新工程(2016-I2M-3-022、2017-I2M-2-004);中央高校基本科研业务费专项(3332018194、3332018115)。

摘　　要：放疗是治疗恶性肿瘤的三大常规手段之一,但由于其存在高辐射剂量损伤正常组织和肿瘤细胞辐射抵抗性强等问题,导致治疗后往往达不到预期效果。为提高放疗疗效,并且减少对正常组织的不良作用,探索新型放疗增敏剂及放化疗联合的新策略已成为研究热点。高分子纳米材料凭借其良好的生物相容性和生理稳定性等优点,为提高肿瘤放疗效果开拓了广阔的应用前景。笔者就高分子纳米材料用于放疗增敏的研究进展进行综述。Radiotherapy is one of the three conventional methods for the treatment of malignant tumors.However,its expected effect is not often achieved because of some limitations,such as normal tissue damage by high radiation dose and the radiation resistance of tumor cells.Thus,exploring new strategies for new radiosensitizers and radio-chemotherapy agents has become a research focus to improve the efficacy of radiotherapy and reduce its side effects on normal tissues.Polymer nanomaterials have broad application prospects in improving the effect of radiotherapy because of their excellent biocompatibility and physiological stability.This article reviews the research progress on polymer nanomaterials for radiosensitization.

关 键 词：辐射增敏药 纳米结构 肿瘤 放射疗法 高分子 

分 类 号：R730.55[医药卫生—肿瘤] R318.08[医药卫生—临床医学]