Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine  

作　　者：Zhan-Jun Ma Jing-Jing Yang Yu-Bao Lu Zhao-Yang Liu Xue-Xi Wang 

机构地区：[1]The Second Clinical Medical College,Lanzhou University,Lanzhou 730000,Gansu Province,China [2]Department of Medical Imaging,Shanxi Medical University,Jinzhong 030600,Shaanxi Province,China [3]School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,Gansu Province,China

出　　处：《World Journal of Stem Cells》2020年第8期814-840,共27页世界干细胞杂志（英文版）（电子版）

摘　　要：Mesenchymal stem cells(MSCs)are multipotent stem cells with marked potential for regenerative medicine because of their strong immunosuppressive and regenerative abilities.The therapeutic effects of MSCs are based in part on their secretion of biologically active factors in extracellular vesicles known as exosomes.Exosomes have a diameter of 30-100 nm and mediate intercellular communication and material exchange.MSC-derived exosomes(MSC-Exos)have potential for cell-free therapy for diseases of,for instance,the kidney,liver,heart,nervous system,and musculoskeletal system.Hence,MSC-Exos are an alternative to MSCbased therapy for regenerative medicine.We review MSC-Exos and their therapeutic potential for a variety of diseases and injuries.

关 键 词：EXOSOMES Mesenchymal stem cells Cell-free therapy Regenerative medicine Mesenchymal stem cell-derived exosomes Extracellular vesicles 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]