机构地区:[1]Department of Gastroenterology,Toyoshima Endoscopy Clinic,Tokyo 157-0066,Japan [2]Department of Gastroenterology,Graduate School of Medicine,The University of Tokyo,Tokyo 113-8655,Japan [3]Department of Gastroenterology and Hepatology,International University of Health and Welfare,Narita Hospital,Chiba 286-8520,Japan [4]Department of Endoscopy and Endoscopic Surgery,Graduate School of Medicine,The University of Tokyo,Tokyo 113-8655,Japan [5]Department of Pathology,Pathology and Cytology Laboratory Japan,Tokyo 166-0003,Japan [6]Department of Gastroenterology and Hepatology,Tokai University School of Medicine,Kanagawa 259-1193,Japan [7]Laboratory of Molecular Medicine,Human Genome Center,Institute of Medical Science,The University of Tokyo,Tokyo 108-8639,Japan [8]Department of Computational Biology and Medical Sciences,Laboratory of Clinical Genome Sequencing,Graduate School of Frontier Sciences,The University of Tokyo,Tokyo 108-8639,Japan
出 处:《World Journal of Gastroenterology》2020年第34期5146-5155,共10页世界胃肠病学杂志(英文版)
基 金:Ministry of Education,Culture,Sports,Science and Technology of Japan,No.25134707 and No.16H01566(to Matsuda K),and No.15K14377(to Tanikawa C);funding from the Tailor-Made Medical Treatment with the BBJ Project from Japan Agency for Medical Research and Development,AMED(from April 2015);and the Ministry of Education,Culture,Sports,Science,and Technology of Japan(from April 2003 to March 2015).
摘 要:BACKGROUND Endoscopy-based Kyoto classification for gastritis and pathological topographic distribution of neutrophil infiltration are correlated with gastric cancer risk.AIM To investigate the association between Kyoto classification and the topographic distribution of neutrophil activity.METHODS Kyoto classification score,ranging from 0 to 8,consisted of atrophy,intestinal metaplasia,enlarged folds,nodularity,and diffuse redness.Neutrophil activity was scored according to the updated Sydney System using biopsy samples obtained from the greater curvature of the corpus and the antrum.The participants were divided into four categories,inactive stomach,antrumpredominant gastritis,pangastritis,and corpus-predominant gastritis,based on the topographic distribution of neutrophil activity.Effects of sex,age,body mass index,drinking habit,smoking habit,family history of gastric cancer,serum Helicobacter pylori(H.pylori)antibody,and Kyoto score on topography of neutrophil infiltration were analyzed.RESULTS A total of 327 patients(comprising 50.7%women,with an average age of 50.2 years)were enrolled in this study.H.pylori infection rate was 82.9%with a mean Kyoto score of 4.63.The Kyoto score was associated with the topographic distribution of neutrophil activity.Kyoto scores were significantly higher in the order of inactive stomach,antrum-predominant gastritis,pangastritis,and corpuspredominant gastritis(3.05,4.57,5.21,and 5.96,respectively).Each individual score of endoscopic findings(i.e.,atrophy,intestinal metaplasia,enlarged folds,nodularity,and diffuse redness)was correlated with the topographic distribution of neutrophil activity.On multivariate analysis,the Kyoto score,age,and serum H.pylori antibody were independently associated with the topographic distribution of neutrophil activity.CONCLUSION The Kyoto classification score was associated with the topographic distribution of neutrophil activity.
关 键 词:Kyoto classification Helicobacter pylori Neutrophil activity Updated Sydney System GASTRITIS Gastric cancer ENDOSCOPY Pathology
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