Simultaneous transcatheter arterial chemoembolization and portal vein embolization for patients with large hepatocellular carcinoma before major hepatectomy  

作　　者：Cheng-Wu Zhang Chang-Wei Dou Xin-Long Zhang Xi-Qiang Liu Dong-Shen Huang Zhi-Ming Hu Jie Liu 

机构地区：[1]Department of Hepatopancreatobiliary Surgery and Minimally Invasive Surgery,Zhejiang Provincial People’s Hospital,People’s Hospital of Hangzhou Medical College,Hangzhou 310014,Zhejiang Province,China [2]Department of General Surgery,Aksu Area First Hospital,Aksu 843000,Xinjiang Uygur Autonomous Region,China

出　　处：《World Journal of Gastroenterology》2020年第30期4489-4500,共12页世界胃肠病学杂志（英文版）

基　　金：Supported by the Medical Health Science and Technology Project of the Zhejiang Provincial Health Commission,No.2016KYA009 and No.2020KY044.

摘　　要：BACKGROUND Sequential transarterial chemoembolization(TACE)and portal vein embolization(PVE)are associated with long time interval that can allow tumor growth and nullify treatments'benefits.AIM To evaluate the effect of simultaneous TACE and PVE for patients with large hepatocellular carcinoma(HCC)prior to elective major hepatectomy.METHODS Fifty-one patients with large HCC who underwent PVE combined with or without TACE prior to hepatectomy were included in this study,with 13 patients in the simultaneous TACE+PVE group,17 patients in the sequential TACE+PVE group,and 21 patients in the PVE-only group.The outcomes of the procedures were compared and analyzed.RESULTS All patients underwent embolization.The mean interval from embolization to surgery,the kinetic growth rate of the future liver remnant(FLR),the degree of tumor size reduction,and complete tumor necrosis were significantly better in the simultaneous TACE+PVE group than in the other groups.Although the patients in the simultaneous TACE+PVE group had a higher transaminase levels after PVE and TACE,they recovered to comparable levels with the other two groups before surgery.The intraoperative course and the complication and mortality rates were similar among the three groups.The overall survival and disease-free survival were higher in the simultaneous TACE+PVE group than in the other two groups.CONCLUSION Simultaneous TACE and PVE is a safe and effective approach to increase FLR volume for patients with large HCC before major hepatectomy.

关 键 词：Transcatheter arterial chemoembolization Portal vein embolization Major hepatectomy Hepatocellular carcinoma Future liver remnant 

分 类 号：R735.7[医药卫生—肿瘤]