“Six-and-twelve” score for outcome prediction of hepatocellular carcinoma following transarterial chemoembolization. In-depth analysis from a multicenter French cohort  

作　　者：Xavier Adhoute Guillaume Pénaranda Jean-Luc Raoul Jean-Pierre Bronowicki Rodolphe Anty MarcBourlière 

机构地区：[1]Department of Gastroenterology and Hepatology,Hôpital Saint-Joseph,Marseille 13008,France [2]AlphaBio Laboratory,Marseille 13003,France [3]Department of Medical Oncology,Institut de Cancérologie de l'Ouest,Nantes 44805,France [4]Department of Gastroenterology and Hepatology,Centre Hospitalo-Universitaire de,Nancy 54511,France [5]Department of Gastroenterology and Hepatology,Hôpital Universitaire de l’Archet,Nice 06200,France

出　　处：《World Journal of Hepatology》2020年第8期525-532,共8页世界肝病学杂志（英文版）（电子版）

摘　　要：The“six-and-twelve”(6&12)score is a new hepatocellular carcinoma(HCC)prognostic index designed for recommended transarterial chemoembolization(TACE)candidates.Quick and easy to use by the sum of tumor size(cm)and number,this model identifies three groups with different survival time(the sum is≤6;or>6 but≤12;or>12);a survival benefit with TACE can be expected for HCC patients with a score not exceeding twelve.Recently,Wang ZW et al showed that the“6&12”model was the best system correlated with radiological response after the first TACE.Thus,we wanted to assess its survival prediction ability as well as its prognostic value and compared it to other systems(Barcelona Clinic Liver Cancer,Hong Kong Liver Cancer(HKLC)staging,Albumin-Bilirubin grade,tumor nodularity,infiltrative nature of the tumor,alpha-fetoprotein,Child-Pugh class,and Performance Status score,Cancer of the Liver Italian Program,Model to Estimate Survival for HCC scores,up-to-seven criteria)different from Wang ZW et al study in a multicenter French cohort of HCC including only recommended TACE candidates retrospectively enrolled.As previously demonstrated,we show that the"6&12”score can classify survival within this French cohort,with a prognostic value comparable to that of other systems,except HKLC staging.More importantly,the“6&12”score simplicity and ability in patients’stratification outperform other systems for a routine clinical practice.

关 键 词：Hepatocellular carcinoma Transarterial chemoembolization “Six-and-twelve”score Prognosis Albumin-Bilirubin grade Tumor nodularity infiltrative nature of the tumor alpha-fetoprotein Child-Pugh class and performance status score 

分 类 号：R735.7[医药卫生—肿瘤]