血清唾液酸检测在脑胶质瘤诊断中的应用  

The application of serum sialic acid test in glioma diagnosis

作　　者：蔡雅君 王永利 Cai Yajun;Wang Yongli(Department of Laboratory,Deqing People′s Hospital,Zhejiang Deqing 313200,China)

机构地区：[1]浙江省德清县人民医院检验科,313200

出　　处：《中国医师进修杂志》2020年第8期750-753,共4页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨血清唾液酸(SA)检测在脑胶质瘤诊断中的应用价值。方法收集2016年1月至2018年12月浙江省德清县人民医院收治的脑胶质瘤患者60例及正常对照者60例,脑胶质瘤患者按照病理分级分为低级别脑胶质瘤组(22例)和高级别脑胶质瘤组(38例)。检测脑胶质瘤患者术前、术后1个月、6个月及正常对照组血清SA水平,并进行比较。结果正常对照组、低级别脑胶质瘤组及高级别脑胶质瘤组的血清SA阳性率分别为1.7%(1/60)、59.1%(13/22)和81.6%(31/38),三组比较差异有统计学意义(χ2=6.49,P<0.05);高级别脑胶质瘤组血清SA阳性率高于低级别脑胶质瘤组及正常对照组,低级别脑胶质瘤组血清SA阳性率高于正常对照组,差异均有统计学意义(P<0.05)。正常对照组、低级别脑胶质瘤组及高级别脑胶质瘤组血清SA水平分别为50.9(46.1 ~ 58.1)、55.6(48.2 ~ 60.9)和64.8(57.9 ~ 73.9)mg/L,三组比较差异有统计学意义(H=15.56,P<0.05);高级别脑胶质瘤组血清SA检测水平高于低级别脑胶质瘤组及正常对照组,低级别脑胶质瘤组血清SA检测水平高于正常对照组,差异均有统计学意义(P<0.05)。术后低级别、高级别脑胶质瘤组SA水平逐渐下降,术后6个月血清SA检测水平与术前比较差异均有统计学意义[低级别脑胶质瘤组:50.4(48.0 ~ 59.1)mg/L比55.6(48.2 ~ 60.9)mg/L;高级别脑胶质瘤组:60.1 (46.0 ~ 62.4)mg/L比64.8(57.9 ~ 73.9)mg/L](P<0.05);低级别脑胶质瘤组术后6个月血清SA检测水平与正常对照组比较差异无统计学意义(P>0.05),而高级别脑胶质瘤组术后6个月血清SA检测水平仍高于正常对照组[60.1(46.0 ~ 62.4)mg/L比50.9(46.1 ~ 58.1)mg/L],且差异有统计学意义(P<0.05)。结论血清SA可用于脑胶质瘤的辅助诊断及预后评估。Objective To explore the clinical value of serum sialic acid(SA)for brain glioma diagnosis.Methods Sixty patients with brain glioma and 60 normal persons(control group)in Deqing People's Hospital from January 2016 to September 2018 were collected,and all the brain glioma patients were divided into low grade group and high grade group according to the pathological grading.The serum SA levels of all the subjects were detected by photocolorimetric method,and the results were analyzed statistically.Results The positive rate of SA in control group,low grade group and high grade group was 1.7%(1/60),59.1%(13/22)and 81.6%(31/38),and there was significant difference(χ2=6.49,P<0.05).The positive rate in high grade group was higher than that in low grade group and control group,the positive rate in low grade group was higher than that in control group,and there was significant difference(P<0.05).The level of SA in control group,low grade group and high grade group was 50.9(46.1-58.1),55.6(48.2-60.9),64.8(57.9-73.9)mg/L,and there was significant difference(H=15.56,P<0.05).The level of SA in high grade group was higher than that in low grade group and control group,the level of SA in low grade group was higher than that in control group,and there was significant difference(P<0.05).After operation,the level of SA was decreased.At 6 months after operation,the level of SA in low grade group and high grade group was significantly lower than that before operation[low grade group:50.4(48.0-59.1)mg/L vs.55.6(48.2-60.9)mg/L;high grade group:60.1(46.0-62.4)mg/L vs.64.8(57.9-73.9)mg/L](P<0.05).At 6 months after operation,the level of SA in high grade group was significantly higher than that in control group[60.1(46.0-62.4)mg/L vs.50.9(46.1-58.1)mg/L](P<0.05),but in lower grade group,there was no significant difference[50.4(48.0-59.1)mg/L vs.50.9(46.1-58.1)mg/L](P>0.05).Conclusions Serum SA can be used in auxiliary diagnosis and prognosis evaluation for brain glioma.

关 键 词：脑胶质瘤 唾液酸 生物学标记 诊断 

分 类 号：R739.41[医药卫生—肿瘤]