NLR及PLR与乳腺癌的相关性研究  

Relationship between NLR,PLR and Breast Cancer

作　　者：刘丛芳 王保祥[1] 邬玉辉[2] 肖志[2] 周薇[1] 王素芳 LIU Cong-fang;WANG Bao-xiang;WU Yu-hui(Health Management Center of Xiangya Hospital,Central South University,Changsha 410000)

机构地区：[1]中南大学湘雅医院健康管理中心,湖南长沙410000 [2]中南大学湘雅医院乳腺外科,湖南长沙410000

出　　处：《医学临床研究》2020年第8期1184-1187,1191,共5页Journal of Clinical Research

摘　　要：【目的】分析外周血血常规中中性粒细胞计数/淋巴细胞计数(NLR)、血小板计数/淋巴细胞计数(PLR)与乳腺癌患者临床病理参数间的相关性。【方法】选取2018年6-12月本院收治的433例乳腺癌患者(乳腺癌组)、健康管理中心体检的631例乳腺BIRADS 1类者(正常组)和309例乳腺BIRADS 2-3类者(乳腺良性疾病组)作为研究对象。收集各组研究对象的年龄、中性粒细胞计数、淋巴细胞计数、血小板计数,同时收集乳腺癌组患者的临床病理资料,包括临床分期、分子分型、病理分级、KI67、淋巴结转移等指标。计算NLR值、血小板计数及淋巴细胞计数计算PLR值。比较正常组、乳腺良性疾病组与乳腺癌组NLR、PLR,分析NLR、PLR与乳腺癌临床病理参数之间的关系。【结果】乳腺癌组、乳腺良性疾病组和正常组三组NLR比较及组间比较差异有统计学意义(P<0.05)。三组PLR比较差异有统计学意义(P<0.05),但在乳腺癌与乳腺良性疾病组、乳腺癌与正常组间比较无明显差异(P>0.05)。绘制ROC曲线评估NLR对乳腺癌的预测价值,ROC曲线下面积(AUC)为0.573,95%CI为0.54-0.606。NLR、PLR与乳腺癌病理分级、Ki67、分子分型均无显著相关性(P>0.05)。但是NLR与乳腺癌淋巴结转移具有相关性(P<0.05),乳腺癌淋巴结转移与NLR呈正相关(rs=0.103,P=0.033)。PLR与乳腺癌淋巴结转移及临床分期具有相关性(P<0.05),乳腺癌淋巴结转移与PLR呈正相关(rs=0.188,P=0.00),与临床分期呈正相关(rs=0.135,P=0.005)。【结论】NLR及PLR的高低可在一定程度上预测患者淋巴结转移情况,PLR与临床分期呈正相关,提示NLR及PLR与乳腺癌患者预后具有一定相关性。【Objective】To analyze the correlation between neutrophil count/lymphocyte count(NLR),platelet count/lymphocyte count(PLR)and clinicopathological parameters in patients with breast cancer.【Methods】Four hundred and thirty-three cases of breast cancer patients(breast cancer group),631 cases of breast BIRADS class 1(normal group)and 309 cases of breast BIRADS 2-3(benign breast disease group)in our hospital from June to December 2018 were selected as the research objects.The age,neutrophil count,lymphocyte count,platelet count of each group were collected,and the clinicopathological data of breast cancer group were collected,including clinical stage,molecular typing,pathological grade,Ki67,lymph node metastasis and other indicators.NLR,platelet count and lymphocyte count were calculated to calculate PLR value.The NLR and PLR of normal group,benign breast disease group and breast cancer group were compared,and the relationship between NLR,PLR and clinicopathological parameters of breast cancer was analyzed.【Results】There were significant differences in NLR among breast cancer group,benign breast disease group and normal group(P<0.05).There was significant difference in PLR among the three groups(P<0.05),but there was no significant difference between breast cancer and benign breast disease group,between breast cancer and normal group(P>0.05).The area under ROC curve(AUC)was 0.573,95%CI was 0.54-0.606.NLR and PLR had no significant correlation with pathological grade,Ki67 and molecular typing of breast cancer(P>0.05).However,NLR was correlated with lymph node metastasis of breast cancer(P<0.05),and was positively correlated with NLR(rs=0.103,P=0.033).PLR was positively correlated with PLR(rs=0.188,P=0.00)and clinical stage(rs=0.135,P=0.005).【Conclusion】The level of NLR and PLR can predict lymph node metastasis to a certain extent.PLR is positively correlated with clinical stage,suggesting that NLR and PLR have certain correlation with prognosis of breast cancer patients.

关 键 词：乳腺肿瘤 比值比 淋巴细胞 中性白细胞 

分 类 号：R737.9[医药卫生—肿瘤]