血塞通联合丁苯酞注射液对脑梗死疗效及NIHSS评分及血流动力学的影响  

Therapeutic Effect of Xuesaitong Injection Combined with Butylphthalide Injection on Cerebral Infarction and Its Effect on NIHSS Score and Hemodynamics

作　　者：王娟[1] 程永红[1] 刘昳知 胡孝勤 李芳秋 WANG Juan;CHENG Yonghong;LIU Yizhi;HU Xiaoqin;LI Fangqiu(Department of Neurology,Zunyi First People's Hospital,Zunyi 563000,Guizhou,China)

机构地区：[1]遵义市第一人民医院神经内科,贵州遵义563000

出　　处：《中华中医药学刊》2020年第8期122-124,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药科学技术研究专项(2017ZX9652)。

摘　　要：目的探讨血塞通注射液联合丁苯酞注射液在脑梗死治疗中的临床价值。方法将2017年2月-2019年1月收治106例急性脑梗死患者以随机数字表法分为对照组53例,观察组53例,均接受常规治疗,对照组加用丁苯酞注射液,观察组在对照组基础上联合血塞通注射液,观察两组治疗效果,治疗前、治疗2周后美国国立卫生研究院卒中量表(NIHSS)、脑卒中特定生活质量量表(SS-QOL)评分及脑血流动力学变化,记录不良反应发生情况。结果总有效率观察组为94.34%,与对照组79.25%对比,明显较高(P<0.05);治疗前,两组NIHSS、SS-QOL评分及脑血流动力学无统计学意义(P>0.05);治疗2周后,观察组NIHSS、SS-QOL评分及大脑中动脉阻力指数(RI)、平均血流速度(Vm)、搏动指数(PI)改善情况均明显优于同期对照组(P<0.05);观察组不良反应发生率为11.32%,与对照组7.55%对比,无统计学意义(P>0.05)。结论脑梗死患者接受血塞通注射液联合丁苯酞注射液治疗,可获得满意疗效,同时能有效降低NIHSS评分,改善脑血流动力学,且安全性良好,具有较高临床价值。Objective To investigate the clinical value of Xuesaitong Injection combined with Butylphthalide Injection in the treatment of cerebral infarction.Methods A total of 106 patients with acute cerebral infarction from Feb 2017 to Jan 2019 were randomly divided into control group(53 cases)and observation group(53 cases).All patients received routine treatment.The control group added Butylphthalide Injection,and the observation group was combined with Xuesaitong Injection on the basis of the control group.We observed the therapeutic effects,the changes of national institutes of health stroke scale(NIHSS),the stroke-specific quality of life scale(SS-QOL)score and cerebral hemodynamic before and 2 weeks after treatment of the two groups,and recorded the adverse reactions.Results The total effective rate was 94.34%in the observation group,and was significantly higher compared with that of the control group(79.25%)(P<0.05).Before treatment,there was no significant difference in NIHSS,SS-QOL score or cerebral hemodynamics between the two groups(P>0.05).After 2 weeks treatment,the improvements of NIHSS,SS-QOL scores,middle cerebral artery resistance index(RI),mean blood flow velocity(Vm)and pulsatility index(PI)in the observation group were significantly better compared with those of the control group at the same time(P<0.05).The incidence of adverse reactions in the observation group was 11.32%.Compared with that of the control group(7.55%),there was no significant difference(P>0.05).Conclusion Patients with cerebral infarction receiving Xuesaitong Injection combined with Butylphthalide Injection can achieve satisfactory results,and can effectively reduce NIHSS score,improve cerebral hemodynamics,has and good safety as well as high clinical value.

关 键 词：脑梗死 血塞通注射液 丁苯酞注射液 神经功能 血流动力学 

分 类 号：R743.3[医药卫生—神经病学与精神病学]