北五味子乙素对力竭运动大鼠心肌氧化应激指标和炎性因子的影响  

Effects of Schisandrae B on Myocardial Oxidative Stress Index and Inflammatory Factor in Rat after Exhaustive Exercise

作　　者：岑人军[1] 张文珍 韦雪亮[1] CEN Renjun;ZHANG Wenzhen;WEI Xueliang(College of Physical Education, Guangxi University,Nanning 530004,China;Guangxi Medical University Stomatological Hospital,Nanning 530021,China)

机构地区：[1]广西大学体育学院,南宁530004 [2]广西医科大学口腔医院,南宁530021

出　　处：《西北农业学报》2020年第9期1310-1316,共7页Acta Agriculturae Boreali-occidentalis Sinica

摘　　要：旨在研究北五味子乙素对于力竭运动模型大鼠心肌氧化应激指标和炎性因子表达水平的影响。购买24只SD大鼠,随机均分为对照组、力竭组和五味子乙素力竭干预组(干预组),对照组大鼠正常喂养不建立力竭模型,力竭组与干预组均缺血为力竭大鼠模型,力竭组不予任何干预,干预组给予北五味子乙素干预;对比各组大鼠心肌组织中脑钠肽(BNP)、血管紧张素Ⅱ(AngⅡ)、超氧化物歧化酶(SOD)、丙二醛(MDA)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)的表达水平。经单因素方差分析,3个组组间大鼠心肌组织BNP、AngⅡ差异有统计学意义(P<0.05);进一步两两对比表明,对照组与力竭组、对照组与干预组、力竭组与干预组BNP差异均有统计学意义(P<0.05),对照组与干预组AngⅡ差异无统计学意义(P>0.05),对照组、干预组分别与力竭组对比AngⅡ差异均有统计学意义(P<0.05);经单因素方差分析,3个组组间大鼠心肌组织的氧化应激指标(SOD、MDA)差异均有统计学意义(P<0.05),进一步两两对比表明,对照组与干预组SOD、MDA差异无统计学意义(P>0.05),对照组、干预组分别与力竭组对比SOD、MDA差异均有统计学意义(P<0.05);经单因素方差分析,3个组组间大鼠心肌组织炎性因子(TNF-α、IL-6、IL-10)差异均有统计学意义(P<0.05);进一步两两对比表明,对照组与力竭组、对照组与干预组、力竭组与干预组TNF-α、IL-10差异均有统计学意义(P<0.05),对照组与干预组IL-6差异无统计学意义(P>0.05),对照组、干预组分别与力竭组对比IL-6差异均有统计学意义(P<0.05)。以上结果说明,五味子乙素对力竭运动大鼠的心肌组织具有明确的抗氧化保护功效。To study the effects of Schisandrin B on myocardial oxidative stress index and inflammatory factor expression in rat after exhaustive exercise.Twenty-four SD rats were purchased and randomly divided into the control group,the exhaustive group and the Schisandra B exhaustion intervention group(intervention group).The control group without exhaustive model was fed normally,but ischemia in the exhaustive group and the intervention group was exhaustive model,among which the the rats in the exhaustive group were not intervened,and the intervention group was intervened with Schisandrin B.Expression levels of brain natriuretic peptide(BNP)and angiotensinⅡ(AngⅡ),superoxide dismutase(SOD),malondialdehyde(MDA),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-10(IL-10)were detected and compared among groups.The differences of BNP and AngⅡin the myocardial tissue of the three groups were statistically significant by one-way analysis of variance(ANOVA)(P<0.05).Further pairwise comparison among the three groups(control group vs.exhaustive group,control group vs.intervention group,and exhaustive group vs.intervention group)showed that there was statistically significant difference in BNP between groups(P<0.05),but the difference in AngⅡbetween the control group and the intervention group was not statistically significant(P>0.05),and the difference was significant in AngⅡcomparing the control group and the intervention group with the exhaustive group,respectively(P<0.05).The differences of SOD and MDA in the three groups were statistically significant by one-way ANOVA(P<0.05).Further pairwise comparison among the three groups showed that there was no significant difference in SOD and MDA between the control group and the intervention group(P>0.05),and there were significant difference in SOD and MDA comparing the control group and the intervention group with the exhaustive group,respectively(P<0.05).Furthermore,the one-way ANOVA revealed statistically significant difference among the three groups in

关 键 词：北五味子乙素 力竭运动 氧化应激 炎性因子 脑钠肽 血管紧张素Ⅱ 

分 类 号：R363.2[医药卫生—病理学]