Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix  

作　　者：Jelena Saponjski Djuro Macut Dragana Sobic-Saranovic Sanja Ognjanovic Ivana Bozic Antic Djordje Pavlovic Vera Artiko 

机构地区：[1]Center for Nuclear Medicine,Clinical Center of Serbia,Belgrade 11000,Serbia [2]Clinic for Endocrinology,Diabetes and Metabolic Diseases,Clinical Center of Serbia,Faculty of Medicine,University of Belgrade,Belgrade 11000,Serbia [3]Center for Nuclear Medicine Clinical Center of Serbia,Faculty of Medicine University of Belgrade,Belgrade 11000,Serbia [4]University Children's Clinic,Belgrade 11000,Serbia

出　　处：《World Journal of Clinical Cases》2020年第17期3697-3707,共11页世界临床病例杂志

基　　金：Ministry of Science,Education and Technology Republic of Serbia,No. 175018。

摘　　要：BACKGROUND Neuroendocrine tumors of appendix(ANETs)known as carcinoids,are rare endocrine neoplasms originated from enterochromaffin cells of gastrointestinal tract.ANETs are the third most frequent(16.7%)gastrointestinal neuroendocrine tumors,with the incidence of 0.08-0.2 cases/100000 during one year.Incidental ANETs occur in 0.2%-0.7%of emergency surgical resections because of suspected appendicitis which is usually the first manifestation of ANET.Although there are a lot of papers about application of somatostatin receptor scintigraphy in gastrointestinal neuroendocrine tumors,there are very rare sporadic cases described about ANETs particularly.AIM To establish the role of somatostatin receptor scintigraphy(SRS)in the management of patients with neuroendocrine tumors of appendix(ANET).METHODS The total of 35 patients was investigated,23 females and 12 males,average age(43.7±17.3 years).All patients had histological diagnosis of ANET(34 carcinoids of appendix and one tubular carcinoid).Majority of tumors have been found incidentally during surgery of:Acute appendicitis(n=15),perforated appendicitis(n=2),ileus(n=3),hysterectomy(n=3),ruptured ovarian cyst(n=2),caecal volvulus(n=1),while 9 patients had diagnosis of appendiceal tumor before the surgery.Seventeen patients had tumor grade(G)G1,12 G2 and 6 G3.The right hemicolectomy was performed in 13,while the rest of the patients had appendectomy only.SRS was done early(2 h)and late(24 h)after i.v.application of 740 MBq technetium-99 m ethylenediamine-N,N’-diacetic acid Hydrazinonicotinyl-Tyr3-Octreotide(technetium-99 m-Tektrotyd,Polatom,Poland).SRS was performed for restaging in all the patients after surgery.RESULTS There were 12 true positive(TP),19 true negative,3 false positive and 1 false negative SRS result.Sensitivity of the method was 92.31%,specificity was 86.36%,positive predictive value was 80.00%,negative predictive value was 95.00%and accuracy 88.57%.Receiver operating characteristics analysis showed that SRS scintigraphy is a good test for detec

关 键 词：Somatostatin receptor scintigraphy CARCINOID APPENDIX Follow up Nuclear medicine RADIONUCLIDE 

分 类 号：R735.36[医药卫生—肿瘤]