基于频数分析和聚类分析研究梗阻性黄疸中医用药规律  

Study on the Regularity of Traditional Chinese Medicine for Obstructive Jaundice Based on Frequency Analysis and Cluster Analysis

作　　者：吴孝雄 陈挺松 韩涛 李京[3] WU Xiaoxiong;CHEN Tingsong;HAN Tao;LI Jing(Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China;Northern Theater General Hospital,Shenyang 110016,Liaoning,China;Liaoning University of Traditional Chinese Medicine,Shenyang 100847,Liaoning,China)

机构地区：[1]上海中医药大学附属第七人民医院,上海200137 [2]北部战区总医院,辽宁沈阳110016 [3]辽宁中医药大学,辽宁沈阳100847

出　　处：《辽宁中医药大学学报》2020年第7期74-77,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81702622);中国博士后科学基金特别资助项目(2017T100827);上海市中医药事业发展三年行动计划(重大研究)(ZYSNXD-CC-ZDYJ025);上海市卫生局青年科研项目(20124Y030)。

摘　　要：目的研究梗阻性黄疸的中医用药规律,并创建临床治疗基本方。方法搜集中国知网数据库中的中医药治疗梗阻性黄疸文献资料,提取方药信息后对中药组成、功效、性味归经按照标准进行数据规范化处理,然后采用频数分析、聚类分析进行统计。结果频数分析显示梗阻性黄疸用药以利水渗湿药、清热药、补虚药为核心,活血、理气、泻下、解表等药常用;药性以寒性为主,温性次之;药味则以苦、甘、辛为主;在归经上以肝、胃、脾居多。通过单味药物频数分析和系统聚类分析归纳出以茵陈蒿汤和大柴胡汤为主的核心药物群,并据此创建梗阻性黄疸中药基本方"茵陈黄柴汤"。结论梗阻性黄疸用药方面以利湿清热为先,辅以补虚、理气、活血、泻下;以肝、胃、脾为主,重视疏肝、和胃、健脾。在使用基本方时辨证加减,根据结石、肿瘤等不同病因加用针对性药物。Objective Discussing the regularity of traditional Chinese medicine for obstructive jaundice and founding basic prescription for clinical therapeutics.Methods First,collecting the literature of TCM treatment of obstructive jaundice in the database of National Knowledge Network,then making standardized data processing for composition,efficacy,nature and flavor of TCM according to standards after extracting information of prescriptions and medicines.At last,make statistics according to frequency analysis and cluster analysis.Results The frequency analysis shows that the drugs which benefit wetting removal of water,antipyretic and tonic medicines plays an important role of the medication for obstructive jaundice.And the drugs of blood circulation,regulating Qi,purgation,diaphoresis and etc are common used.Induced that Yinchenhao Decoction and Dachaihu Decoction are core drug groups according to frequency analysis and cluster analysis.And on the base of this result,establishing the basic prescription of TCM for obstructive jaundice,which called"Yinchen Huangchai Decoction".Conclusion Drugs of dampnessing and clearing heat are firstly used to treat obstructive jaundice,and the drugs of tonic,blood circulation,regulating Qi and purgation are used as auxiliary function.Liver,stomach and spleen give first place to treat obstructive jaundice,and also concentrated on soothing liver,harmonizing stomach and invigorating spleen to cure it.Make dialectical addition and subtraction when use the basic prescription,and add targeted herbal medicine according to different causes like the different kinds of calculuses and tumours.

关 键 词：梗阻性黄疸 频数分析 聚类分析 用药规律 

分 类 号：R575[医药卫生—消化系统]