黑色素瘤发病过程中与肿瘤相关成纤维细胞间的相互作用  

Interaction with Cancer-Associated Fibroblasts in Pathogenesis of Melanoma

作　　者：胡泰然[1] 雷铁池[1] HU Tairan;LEI Tiechi(Department of Dermatology,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院皮肤科,武汉430060

出　　处：《医学综述》2020年第17期3411-3415,共5页Medical Recapitulate

基　　金：国家自然科学基金(81573028)。

摘　　要：黑色素瘤是一种侵袭力强、恶性程度高的肿瘤,起源于皮肤黑素细胞的恶性转化,并被肿瘤相关成纤维细胞(CAFs)等浸润。CAFs作为肿瘤微环境的重要组成部分,其与黑色素瘤间的相互作用在黑色素瘤的发病过程中起着十分关键的作用。黑色素瘤主要通过旁分泌方式诱导正常成纤维细胞活化成为CAFs;同时,活化的CAFs又可作用于黑色素瘤,促进黑色素瘤的生长、侵袭、致密结构形成、血管形成、转移甚至耐药。因此,对黑色素瘤与CAFs间相互作用机制的深入研究将有助于发现黑色素瘤治疗的新靶点。Melanoma is a highly invasive and malignant tumor,which originates from the malignant transformation of skin melanocytes and is infiltrated by cancer-associated fibroblasts(CAFs).CAFs are an important part of the tumor microenvironment.Interactions between CAFs and melanoma are critical in the pathogenesis of melanoma.Melanoma mainly induces the activation of normal fibroblast into CAFs by paracrine;at the same time,the activated CAFs in turn act on melanoma,promoting the growth,invasion,compact structure formation,angiogenesis,metastasis,and even drug resistance of melanoma.Therefore,in-depth study on the interaction mechanisms between melanoma and CAFs will help to discover new therapeutic targets for melanoma.

关 键 词：黑色素瘤 肿瘤相关成纤维细胞 肿瘤微环境 旁分泌 外泌体 

分 类 号：R739.5[医药卫生—肿瘤]