宫颈锥切术后CIN残留及复发相关影响因素的研究进展  

Research Development of Residual and Recurrence Risk Factors after Conization of Cervical Intraepithelial Neoplasia

作　　者：魏至瑶 代荫梅[1] WEI Zhiyao;DAI Yinmei(Department of Gynecology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China)

机构地区：[1]首都医科大学附属北京妇产医院妇科,北京100026

出　　处：《医学综述》2020年第17期3416-3420,3428,共6页Medical Recapitulate

基　　金：北京市科技计划课题(z161100000116065)。

摘　　要：宫颈上皮内瘤变(CIN)是常见的宫颈癌前病变,可发展为子宫颈浸润癌。大部分宫颈低级别鳞状上皮内病变具有逆转倾向,可自然消退,但宫颈高级别鳞状上皮内病变(HSIL)需要治疗,多采取保留生育功能的宫颈锥切术进行治疗。多种因素(如年龄、绝经状态、吸烟史、孕产次)均可影响宫颈锥切术后HSIL的病灶残留及复发,除绝经状态外,其他影响因素对宫颈锥切术后HSIL的病灶残留及复发的影响尚有争议。此外,CIN病变范围及其累及腺体、术后高危型人乳头瘤病毒的高载量及持续感染、术后病理切缘阳性等均可能是CIN复发的相关危险因素。Cervical intraepithelial neoplasia(CIN)is a common cervical precancerous lesion,which can develop into cervical invasive cancer.Most of the low-grade squamous intraepithelial lesions of the cervix have the tendency of reversion,which can disappear naturally,but the high-grade squamous intraepithelial lesions(HSIL)of the cervix need to be treated,and the cervical conization with preserved fertility function is often used.Multiple factors(such as age,menopausal state,smoking history,pregnancy and delivery times)can affect the residual and recurrence of HSIL after cervical conization.In addition to menopausal state,whether other factors have influence on the residual and recurrence of HSIL after cervical conization is still controversial.In addition,the extent of CIN and its involvement of glands,high load of high-risk human papillomavirus and persistent infection after operation,and positive pathological margin may all be the risk factors of CIN recurrence.

关 键 词：宫颈高级别鳞状上皮内病变 宫颈锥切术 病灶残留 复发 

分 类 号：R737.33[医药卫生—肿瘤]