miRNAs调控鼻咽癌放疗抵抗的研究进展  

Research Progress of miRNAs in Regulating Radiotherapy Resistance of Nasopharyngeal Carcinoma

作　　者：田雨桐 饶珊 潘青[1,2] 曹岱 谭世铭 周钰娟 TIAN Yutong;RAO Shan;PAN Qing;CAO Dai;TAN Shiming;ZHOU Yujuan(University of South China,Hengyang,Hunan,421001,China;Central Laboratory,Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha,Hunan,410013,China)

机构地区：[1]南华大学,湖南衡阳421001 [2]湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院中心实验室,湖南长沙410013

出　　处：《肿瘤药学》2020年第4期385-390,415,共7页Anti-Tumor Pharmacy

基　　金：湖南省自然科学基金(2019JJ40175);国家癌症中心攀登基金(NCC2018B68)。

摘　　要：鼻咽癌是东南亚以及我国南方地区最常见的头颈部恶性肿瘤,放射治疗已成为鼻咽癌最主要的治疗手段,但因放疗抵抗常导致鼻咽癌治疗失败。miRNAs是一类长约22 nt(19~25 nt)的内源性非编码RNA,在肿瘤细胞的增殖、侵袭和转移过程中发挥着重要作用。近年来,越来越多的研究发现,miRNAs广泛参与了鼻咽癌的发生、发展等过程,在不同放射敏感性的鼻咽癌中的表达存在明显差异,并参与鼻咽癌细胞放射敏感性的调控。本文就miRNAs调控鼻咽癌放疗抵抗的研究进展进行简要综述。Nasopharyngeal cancer is the most common head and neck malignant tumor in Southeast Asia and southern China.Radiation therapy has become the main treatment for nasopharyngeal carcinoma,but radiotherapy resistance often leads to the failure of nasopharyngeal carcinoma treatment.miRNAs,about 22 nt(19~25 nt)long,play an important role in the proliferation,invasion and metastasis of tumor cells.In recent years,more and more studies have found that miRNAs are widely involved in the occurrence and development of nasopharyngeal carcinoma.miRNAs have significant differential expressions in nasopharyngeal carcinomas with different radiosensitivities and participate in radiosensitivity of nasopharyngeal carcinoma cells.Here,we review the research progress of miRNAs in regulating radiotherapy resistance in nasopharyngeal carcinoma.

关 键 词：MIRNAS 鼻咽癌 放射治疗 放疗抵抗 

分 类 号：R739.6[医药卫生—肿瘤]