鼻腔鼻窦少见恶性肿瘤的组织病理学和综合性治疗研究进展  

Advances in histopathology and comprehensive treatment of rare malignant tumors in paranasal sinuses

作　　者：李锦荣 夏立军[2] 李梦婷 LI Jinrong;XIA Lijun;LI Mengting(Shanxi Medical University,Taiyuan 030001,China;Department of Otolaryngology Head and Neck Surgery,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学,山西太原030001 [2]山西医科大学第一医院耳鼻喉头颈外科,山西太原030001

出　　处：《中国耳鼻咽喉颅底外科杂志》2020年第4期456-461,共6页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：鼻窦鼻腔恶性肿瘤(SNM)发病率较低,早期症状及体征无特异性,大多具有侵袭性强、易发生淋巴结及远处转移、预后差等特点,临床诊断难度较大。SUM病理类型繁多,其中鳞癌占60%以上,腺癌次之。目前关于SUM的报道多为单一的病理类型研究,多病理综合性研究缺乏,本文对双表型鼻窦鼻腔肉瘤(BSNS)、鼻腔鼻窦畸胎癌肉瘤(SNTCS)、中线癌(NMC)、鼻腔鼻窦神经内分泌癌(SNEC)等少见SNM的临床特点、组织病理学、分子遗传学及其综合治疗的最新研究进展进行综述。The incidence of sinonasal malignancies(SNM)is relatively low,the early symptoms and signs are not specific.The most OF SNM are characterized by strong invasiveness,easy lymph node metastasis and distant metastasis,and poor prognosis.Therefore,it is difficult to make clinical diagnosis.There are various pathological types of SNM,which are more than 60%for squamous cell carcinoma,followed by adenoma.At present,most reports on SNM are studies of single pathological type,and comprehensive studies on multi-pathology of SNM are lacking.In this paper,we reviewed the clinical features,histopathology,molecular genetics and comprehensive treatment of Biphenotypic sinonasal sarcoma(BSNS),Sinonasal teratocarcino sarcoma(SNTCS),NUT midline carcinoma(NMC),small cell neuroendocrine carcinomas(SNEC)and other rare SNMS.

关 键 词：鼻肿瘤 免疫组化 分子遗传学特征 肿瘤综合治疗方案 

分 类 号：R739.62[医药卫生—肿瘤]