FOXP3在胃癌组织中的表达对临床分期及预后的影响  

Effect of FOXP3 expression in gastric cancer on clinical stage and prognosis

作　　者：王钟林[1] 邱磊[1] 冯传波[1] 王刚[1] 邵华[1] 苗永昌[1] Wang Zhonglin;Qiu Lei;Feng Chuanbo;Wang Gang;Shao Hua;Miao Yongchang(Department of Gastrointestinal Surgery,the Second People′s Hospital of Lianyungang city,Lianyungang 222006,China)

机构地区：[1]连云港市第二人民医院胃肠外科,连云港222006

出　　处：《国际外科学杂志》2020年第8期522-526,F0003,共6页International Journal of Surgery

基　　金：连云港市医学创新团队项目;连云港市“科教强卫工程”青年科技项目(QN1607)。

摘　　要：目的研究FOXP3在胃癌组织中的表达水平及其对预后的指导意义。方法选取2005年1月-2015年12月连云港市第二人民医院胃肠外科收治的106例病理确诊为胃腺癌的标本作为观察组,85例正常癌旁组织作为对照组。采用组织芯片及免疫组化技术检测106例胃癌组织中FOXP3的表达情况,采用Cox回归模型分析生存资料与预后的相关性,采用Kaplan-Meiers分析FOXP3表达和胃癌患者预后之间的关系。结果胃癌组织中FOXP3表达阳性率为53.8%(57/106),癌旁组织中FOXP3表达阳性率为28.2%(24/85),两者比较差异有统计学意义(χ^2=12.597,P<0.01)。胃癌组织中FOXP3表达水平与患者年龄、性别、肿瘤分化程度、肿瘤大小和淋巴结转移无相关性(P>0.05),与肿瘤TNM分期明显相关(χ^2=4.402,P<0.05)。单因素Cox生存分析结果表明,年龄、肿瘤病理分级、肿瘤大小、是否侵犯淋巴结、TNM分期、FOXP3表达水平和预后相关(P<0.05)。Kaplan-Meier生存分析表明肿瘤细胞FOXP3阳性组生存率低于FOXP3阴性组;在亚组分型中,任何年龄、性别、Ⅲ、Ⅳ期肿瘤细胞Ⅲ组、低分化和未分化组、肿瘤大小、<16 cm3组、侵犯淋巴结组,肿瘤细胞FOXP3表达阳性组生存率均低于肿瘤细胞FOXP3表达阴性组。结论胃癌组织中FOXP3表达上调,胃癌组织中FOXP3表达可能是胃癌预后的影响因素,肿瘤细胞FOXP3表达阳性可能提示更差的预后。Objective To study the expression of FOXP3 in gastric cancer and its prognostic significance.Methods One hundred and six specimens of gastric adenocarcinoma confirmed by pathology from the Department of Gastrointestinal Surgery of the Second People′s Hospital of Lianyungang in Jan.2005 to Dec.2015 were selected as the observation group and 85 normal para-cancer tissues as the control group.The expression of FOXP3 in 106 cases of gastric cancer was detected by tissue microarray and immunohistochemical technology.Cox regression model was used to analyze the correlation between survival data and prognosis,and Kaplan-Meiers was used to analyze the relationship between FOXP3 expression and the prognosis of gastric cancer patients.Results The positive rate of FOXP3 expression was 53.8%(57/106)in gastric cancer tissues and 28.2%(24/85)in paraneoplastic tissues,and the difference was statistically significant(χ^2=12.597,P<0.001).The level of FOXP3 expression in gastric cancer tissues was significantly correlated with the TNM stage of patients′tumors(χ^2=4.402,P<0.05).Single-factor Cox survival analysis showed that age,tumor pathological grade,tumor size,whether it invaded lymph nodes,TNM stage,FOXP3 expression level and prognosis were correlated.Kaplan-Meier survival analysis showed that the survival rate of tumor cell FOXP3-positive group was lower than that of FOXP3-negative group;in the subgroup type,among the subgroups,any age group,any sex group,stageⅢandⅣtumor cell subgroups,low-and undifferentiated groups,tumor size<16 cm3 group,and tumor cell FOXP3 expression-positive group invading lymph nodes had lower survival than tumor cell FOXP3 expression-negative group.Conclusions The expression of FOXP3 is up-regulated in gastric cancer.The expression of FOXP3 in gastric cancer may be a prognostic factor,and the positive expression of FOXP3 may indicate a worse prognosis.

关 键 词：胃肿瘤 预后 肿瘤分期 叉头样转录因子 总体生存率 

分 类 号：R735.2[医药卫生—肿瘤]