血清卵泡抑素样蛋白-1水平对急性脑梗死后出血转化的预测价值  

Predictive value of serum follistatin like protein-1 level on hemorrhagic transformation after acute cerebral infarction

作　　者：吴月菊 高阳 WU Yueju;GAO Yang(Xuzhou Medical University,Xuzhou 221004,China;不详)

机构地区：[1]徐州医科大学,江苏徐州221004 [2]盐城市第一人民医院

出　　处：《山东医药》2020年第25期22-25,共4页Shandong Medical Journal

基　　金：江苏省自然科学基金项目(BK20161041)。

摘　　要：目的探讨血清卵泡抑素样蛋白-1(FSTL1)与急性脑梗死(ACI)后出血转化(HT)的关系,分析FSTL1对ACI后发生HT的预测价值。方法选择103例ACI患者,根据是否发生HT分为HT组(43例)和NHT组(60例),同时选择53例健康志愿者作为对照组。检测三组血清FSTL1水平。采用Logistic回归分析血清FSTL1水平与ACI后HT的关系,采用受试者工作特征(ROC)曲线分析FSTL1预测ACI后HT的价值。结果HT组、NHT组血清FSTL1水平均高于对照组,HT组血清FSTL1水平高于NHT组(P均<0.01)。Logistic回归分析结果显示,FSTL1水平与ACI后HT密切相关(OR=1.732,95%CI:1.506~2.351,P=0.000)。ROC曲线分析结果显示,血清FSTL1水平预测ACI后HT的曲线下面积为0.846,灵敏度、特异度分别为86.05%、86.67%。结论ACI后HT患者血清FSTL1水平升高,高水平FSTL1可作为ACI患者发生HT的预测因子。Objective To investigate the relationship between serum follistatin like protein-1(FSTL1)and hemorrhagic transformation(HT)after acute cerebral infarction(ACI),and to analyze the predictive value of FSTL1 on HT after ACI.Methods Totally 103 patients with ACI were selected and divided into the HT group(43 cases)and NHT group(60 cases)according to the occurrence of HT,and 53 healthy volunteers were selected as the control group.The level of serum FSTL1 was detected.Logistic regression was used to analyze the relationship between serum FSTL1 level and HT after ACI.Receiver operating characteristic(ROC)curve was used to analyze the value of FSTL1 in predicting HT after ACI.Results The serum FSTL1 levels in the HT group and NHT group were higher than that in the control group,and serum FSTL1 level in the HT group was higher than that in the NHT group(all P<0.01).Logistic regression analysis showed that FSTL1 level was closely related to HT after ACI(OR=1.732,95%CI:1.506-2.351,P=0.000).ROC analysis showed that the area under the curve of serum FSTL1 level in predicting HT after ACI was 0.846,and the sensitivity and specificity were 86.05%and 86.67%,respectively.Conclusion The serum FSTL1 level in HT patients after ACI increases,and the high level of FSTL1 can be used as a predictor of HT in ACI patients.

关 键 词：急性脑梗死 卵泡抑素样蛋白-1 出血转化 预测分析 

分 类 号：R743.33[医药卫生—神经病学与精神病学]