中国部分地区基于社区人群胃食管反流病患病率Meta分析  

Meta-analysis of the prevalence of gastroesophageal reflux disease based on community population in some areas of China

作　　者：周金池 赵曙光[1] 王新[1] 魏延 韩伟[1] 程浩 李丽丽 窦维佳 刘震雄[1] ZHOU Jinchi;ZHAO Shuguang;WANG Xin;WEI Yan;HAN Wei;CHENG Hao;LI Lili;DOU Weijia;LIU Zhenxiong(Department of Gastroenterology,Tangdu Hospital,Air Force Military Medical University,Xi’an 710038;Liujiawa Health Center,Wangzhuang Town,Chengcheng County,Weinan City,Shaanxi Province,China)

机构地区：[1]中国人民解放军空军军医大学唐都医院消化内科,陕西西安710038 [2]陕西省渭南市澄城县王庄镇刘家洼卫生院

出　　处：《胃肠病学和肝病学杂志》2020年第9期1012-1020,共9页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的通过Meta分析系统评价2000年至2019年中国部分地区社区人群胃食管反流病(gastroesophageal reflux disease,GERD)患病率情况。方法通过计算机检索CBM、CNKI、维普、PubMed、EMbase数据库,收集2000年至2019年发表的中国社区人群GERD患病情况的横断面研究。2名独立研究者利用NoteExpress和Endnote x8文献管理软件进行文献梳理,提取数据,采用Stata 12.0软件进行患病率的Meta分析。结果共纳入34篇文献,总计100231例受调查者。结果显示,中国社区人群GERD患病率为7.69%(95%CI:5.95%~9.63%)。亚组分析显示:评价标准:RDQ量表结果显示GERD诊断率为6.83%(95%CI:5.06%~8.87%),GERDQ量表显示诊断率为9.81%(95%CI:6.00%~14.42%),其他问卷结果显示,诊断率为7.80%(95%CI:2.85%~14.95%)(P<0.05)。地区差异:西北地区患病率最高8.99%(95%CI:6.44%~11.95%),华东地区患病率最低5.88%(95%CI:2.51%~10.56%)(P<0.05)。性别差异:男性8.51%(95%CI:6.12%~11.25%),女性8.29%(95%CI:5.93%~11.00%)(P<0.05)。城乡差异:农村患病率6.88%(95%CI:5.49%~8.45%),城市患病率6.73%(95%CI:4.51%~9.34%)(P>0.05)。结论中国人群GERD总体患病率7.69%,GERDQ诊断率高于RDQ;GERD患病率总体呈现西高东低趋势,男性患病率高于女性,城乡之间差异无统计学意义。Objective To evaluate the prevalence of gastroesophageal reflux disease(GERD)based on community population in some areas of China from 2000 to 2019.Methods Cross-sectional studys of GERD in Chinese community population published from 2000 to 2019 were collected through searching of CBM,CNKI,VIP,PubMed and EMbase databases.Two independent researchers used NoteExpress and Endnote x8 literature management softwares to conduct literature review,extract data,and Meta-analysis was conducted by Stata 12.0 software.Results A total of 34 articles were included,with a total of 100231 subjects.The results showed that the prevalence of GERD in Chinese community was 7.69%(95%CI:5.95%-9.63%).Subgroup analysis showed that:in evaluation criterion,the diagnostic rate of GERD based on RDQ questionnaire was 6.83%(95%CI:5.06%-8.87%),the diagnostic rate based on GERDQ questionnaire was 9.81%(95%CI:6.00%-14.42%),and the diagnostic rate based on other questionnaires was 7.80%(95%CI:2.85%-14.95%)(P<0.05);In regional differences,the highest prevalence diagnostic rate was in the northwest with 8.99%(95%CI:6.44%-11.95%),and east of China was the lowest with 5.88%(95%CI:2.51%-10.56%)(P<0.05).In gender differences,the prevalence of males was 8.51%(95%CI:6.12%-11.25%)and females was 8.29%(95%CI:5.93%-11.00%)(P<0.05).In urban rural differences,the rural prevalence was 6.88%(95%CI:5.49%-8.45%)and the urban prevalence was 6.73%(95%CI:4.51%-9.34%)(P>0.05).Conclusion The overall prevalence of GERD in Chinese population is 7.69%,and the diagnostic rate of GERDQ is higher than that of RDQ.The prevalence of GERD is the highest in the northwest and the lowest in the east.The prevalence rate is higher in males than that in females.There are no differences between urban and rural areas.

关 键 词：胃食管反流病 社区人群 患病率 META分析 

分 类 号：R57[医药卫生—消化系统]