结直肠息肉发病相关危险因素分析  

Analysis of risk factors associated with colorectal polyps

作　　者：李文洁 商春雨 桑慧 周颖[1] 朱宏[1] LI Wenjie;SHANG Chunyu;SANG Hui;ZHOU Ying;ZHU Hong(Department of Gastroenterology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院消化内科,江苏南京210029

出　　处：《胃肠病学和肝病学杂志》2020年第9期1037-1041,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：江苏省六大人才高峰(WSN-030);江苏省“333”工程项目(LGY2016010);南京市科技局项目(201715003)。

摘　　要：目的探讨结直肠息肉发病及不同病理类型的危险因素,为结直肠息肉病因研究和建立有效干预措施提供临床依据。方法收集结直肠息肉患者1439例(病例组),其中非腺瘤性息肉485例,腺瘤性息肉954例,肠镜检查未见明显异常者278名为对照组。收集性别、年龄、BMI、饮食习惯、运动、H.pylori感染、脂肪肝、胆囊结石、胆囊息肉、高血压、糖尿病、高脂血症、冠心病、便秘、腹泻、吸烟、饮酒等临床资料。比较病例组与对照组及不同病理类型息肉者的上述各指标差异。采用多因素Logistic回归分析结直肠息肉发病及不同病理类型的危险因素。结果病例组与对照组在性别、年龄分布上差异有统计学意义(P<0.05),病例组在具有高BMI值、高脂血症、特殊饮食嗜好(红肉、辛辣、油腻、高盐、水果)、吸烟、饮酒、H.pylori感染、脂肪肝、高血压、糖尿病、便秘等因素人群中更为多见(P<0.05)。其中高龄、高脂血症、H.pylori感染、便秘、吸烟及饮酒是结直肠息肉发生的独立危险因素(P<0.05)。息肉组内,腺瘤性息肉和非腺瘤性息肉相比,高龄、高脂血症、饮酒是腺瘤性息肉的独立危险因素(P<0.05),单次、多发、大息肉的病理类型以结直肠腺瘤性息肉多见(P<0.05)。结论高龄、高脂血症、H.pylori感染、便秘、吸烟及饮酒是结直肠息肉发病的独立危险因素,高龄、高脂血症、饮酒是腺瘤性息肉发生的独立危险因素,单次、多发、大息肉的病理类型以结直肠腺瘤性息肉多见。Objective To investigate the risk factors of colorectal polyps and different pathological types,so as to provide the clinical basis for the study of the causes of colorectal polyps and the establishment of effective interventions.Methods A total of 1439 patients with colorectal polyps were collected(case group),including 485 cases of nonadenomatous polyps and 954 cases of adenomatous polyps.278 people with no obvious abnormalities in colonoscopy were collected as the control group.Data on sex,age,BMI,diet(red meat,spicy,greasy,high salt,vegetables,fruits),exercise,H.pylori infection,fatty liver,gallstone,gallbladder polyp,hypertension,diabetes,hyperlipidemia,coronary heart disease,constipation,diarrhea,smoking,drinking,etc.were collected.To compare the above indexes of the case group and the control group,and to compare the above indexes of different pathological types of polyps.Multivariate Logistic regression was used to analyze the risk of colorectal polyps and different pathological types.Results There were differences in gender and age distribution between the case group and the control group(P<0.05).The case group was more common in patients with high BMI,hyperlipidemia,special eating habits(red meat,spicy,greasy,high salt,fruits),smoking,drinking,H.pylori infection,fatty liver,hypertension,diabetes,constipation factors(P<0.05).Among them,advanced age,hyperlipidemia,H.pylori infection,constipation,smoking and drinking were independent risk factors of colorectal polyps(P<0.05).In the polyp group,compared with non-adenomatous polyps,advanced age,hyperlipidemia and drinking were independent risk factors of colorectal polyps(P<0.05).The pathological types of single,multiple,and large polyps were more common in colorectal adenomatous polyps(P<0.05).Conclusion Advanced age,hyperlipidemia,H.pylori infection,constipation,smoking and drinking were the independent risk factors of colorectal polyps,and advanced age,hyperlipidemia and drinking were the independent risk factors of adenomatous polyps.The pathological typ

关 键 词：结直肠息肉 危险因素 病理类型 相关性 

分 类 号：R574[医药卫生—消化系统]