Improving control effects of absence seizures using single-pulse alternately resetting stimulation (SARS) of corticothalamic circuit  

作　　者：Denggui FAN Yanhong ZHENG Zecheng YANG Qingyun WANG 

机构地区：[1]School of Mathematics and Physics,University of Science and Technology Beijing,Beijing 100083,China [2]College of Mathematics and Informatics,Fujian Normal University,Fuzhou 350117,China [3]Department of Dynamics and Control,Beihang University,Beijing 100191,China

出　　处：《Applied Mathematics and Mechanics(English Edition)》2020年第9期1287-1302,共16页应用数学和力学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China(Nos.11702018,11932003,and 11672074)。

摘　　要：Presently,we develop a simplified corticothalamic(SCT)model and propose a single-pulse alternately resetting stimulation(SARS)with sequentially applying anodic(A,“+”)or cathodic(C,“−”)phase pulses to the thalamic reticular(RE)nuclei,thalamus-cortex(TC)relay nuclei,and cortical excitatory(EX)neurons,respectively.Abatement effects of ACC-SARS of RE,TC,and EX for the 2 Hz-4 Hz spike and wave discharges(SWD)of absence seizures are then concerned.The m∶n on-off ACC-SARS protocol is shown to effectively reduce the SWD with the least current consumption.In particular,when its frequency is out of the 2 Hz-4 Hz SWD dominant rhythm,the desired seizure abatements can be obtained,which can be further improved by our proposed directional steering(DS)stimulation.The dynamical explanations for the SARS induced seizure abatements are lastly given by calculating the averaged mean firing rate(AMFR)of neurons and triggering averaged mean firing rates(TAMFRs)of 2 Hz-4 Hz SWD.

关 键 词：epileptic absence seizure spike and wave discharge(SWD) single-pulse alternately resetting stimulation(SARS) mean field model averaged mean firing rate(AMFR) seizure control 

分 类 号：O175[理学—数学] O322[理学—基础数学]