丁苯酞软胶囊联合脑蛋白水解物对急性脑梗死患者NIHSS评分及Keap1-Nrf2/ARE信号传导通路的影响  

Effects of Butylphthalide Soft Capsule Combined with Brain Protein Hydrolysate on NIHSS Score and Keap1-Nrf2/ARE Signaling Pathway in Patients with Acute Cerebral Infarction

作　　者：张立攀[1] 朱云亮[1] ZHANG Lipan;ZHU Yunliang(The Affiliated Hospital of Shandong Jining Medical College, Shandong Jining 272029, China)

机构地区：[1]济宁医学院附属医院,山东济宁272029

出　　处：《河北医学》2020年第9期1454-1460,共7页Hebei Medicine

基　　金：山东省医药卫生科技发展计划项目,(编号:2017WS140)。

摘　　要：目的:探讨丁苯酞软胶囊联合脑蛋白水解物对急性脑梗死(ACI)患者神经功能(NIHSS)评分及Keap1-Nrf2/ARE信号传导通路的影响。方法:选取2016年8月至2019年7月我院93例ACI患者作为研究对象,简单随机分组,各31例。三组均予以常规治疗,于此基础上,对照A组予以脑蛋白水解物治疗,对照B组予以丁苯酞软胶囊治疗,观察组予以蛋白质水解物联合丁苯酞软胶囊治疗。统计对比三组临床疗效及治疗前后血管性假血友病因子(vWF)、脂联素(APN)、白介素(IL)-8、IL-19、肿瘤坏死因子(TNF)-α、超氧化物歧化酶(SOD)、丙二醛(MDA)、Keap1-Nrf2/ARE信号传导通路相关蛋白水平、NIHSS评分、日常生活活动能力(Barthel指数)。结果:观察组临床疗效高于对照A、B组(P<0.05);疗程结束后,观察组NIHSS评分低于对照A、B组,Barthel指数高于对照A、B组(P<0.05);疗程结束后,观察组血清vWF、MDA水平低于对照A、B组,APN、SOD水平高于对照A、B组(P<0.05);疗程结束后,观察组血清IL-19、IL-8、TNF-α水平低于对照A、B组(P<0.05);疗程结束后,观察组Keap1表达水平低于对照A、B组,NQO1、ARE、Nrf2表达水平高于对照A、B组(P<0.05)。结论:丁苯酞软胶囊联合脑蛋白水解物治疗ACI,可明显改善患者血管内皮功能,抑制氧化应激反应及炎症反应,调节Keap1-Nrf2/ARE信号传导通路相关蛋白,改善神经功能及日常生活活动能力,效果较为显著。Objective To investigate the effects of butylphthalide soft capsule combined with brain protein hydrolysate on neurological function(NIHSS)score and Keap1-Nrf2/ARE signaling pathway in patients with acute cerebral infarction(ACI).Methods:From August 2016 to July 2019,93 patients with ACI in our hospital were selected as the research objects,and they were simply randomized into 3 groups,with 31 cases in each.Besides conventional treatment,control group A was also treated with brain protein hydrolysate,and the control group B was additionally treated with butylphthalide soft capsules,and the observation group was treated with protein hydrolysate combined with butylphthalide soft capsule.The clinical efficacy and vascular pseudohemophilic factor(VWF),adiponectin(APN),interleukin(IL)-8,IL-19,tumor necrosis factor(TNF)-α,superoxide Dismutase(SOD),malondialdehyde(MDA),Keap1-Nrf2/ARE signalling pathway-related protein levels,NIHSS scores,and daily living(Barthel index)of the three groups were compared statistically.Results:The clinical efficacy of the observation group was higher than that of control groups A and B(P<0.05).After the course of treatment,the NIHSS score of the observation group was lower than those of control groups A and B,and the Barthel index was higher than that of control groups A and B(P<0.05).After the treatment course,the serum VWF and MDA levels in the observation group were lower than those in the control groups,and the APN and SOD levels were higher than those in the control groups(P<0.05).After the course of treatment,the serum levels of IL-19,IL-8 and TNF-αin the observation group were lower than those in the control groups(P<0.05).After the treatment course,the expression level of Keap1 in the observation group was lower than that in the control groups,and the expression levels of NQO1,ARE,and Nrf2 were higher than those in the control groups(P<0.05).Conclusion:Butylphthalide soft capsule combined with brain protein hydrolysate for the treatment of ACI can obviously improve the vascular en

关 键 词：急性脑梗死 丁苯酞软胶囊 脑蛋白水解物 Keap1-Nrf2/ARE信号传导通路 

分 类 号：R74[医药卫生—神经病学与精神病学]