依达拉奉对颅内动脉瘤夹闭术患者神经功能保护作用及其与血清D-二聚体总胆红素水平的关系  

Protective Effect of Edaravone on Nerve Function and Its Relationship with Serum D-Dimer and Total Bilirubin Levels in Patients Undergoing Intracranial Aneurysm Clipping

作　　者：王鹏[1] 海澜 WANG Peng;HAI Lan(The First People's Hospital of Tianshui, Gansu Tianshui 741000, China)

机构地区：[1]甘肃省天水市第一人民医院,甘肃天水741000

出　　处：《河北医学》2020年第9期1469-1472,共4页Hebei Medicine

基　　金：甘肃省卫生厅科研基金项目,(编号:2016D01954)。

摘　　要：目的:探讨依达拉奉对颅内动脉瘤夹闭术患者神经功能、血清D-二聚体、总胆红素水平的影响,并分析患者治疗后的神经功能与血清D-二聚体、总胆红素水平的相关性。方法:选取2018年1月至2019年9月我院收治的颅内动脉瘤夹闭术患者60例,简单随机分组分为观察组与对照组各30例。两组患者均进行常规治疗(应用白蛋白、多巴胺、低分子右旋糖酐、甘露醇),持续10d;观察组在此基础上应用依达拉奉,持续14d。比较两组患者的NIHSS评分、血清D-二聚体和总胆红素水平、预后。结果:观察组治疗前与治疗14d后NIHSS评分、D-二聚体、总胆红素水平的差值均高于对照组(P<0.05)。治疗14d后的血清D-二聚体水平与NIHSS评分呈正相关(r=0.426,P<0.05);血清总胆红素水平与NIHSS评分呈负相关(r=-0.359,P<0.05)。治疗3个月后,观察组预后良好率为70.00%,高于对照组的43.33%(P<0.05)。结论:颅内动脉瘤夹闭术后应用依达拉奉治疗,具有神经功能保护作用,且与血清D-二聚体、总胆红素水平变化有一定关系。Objective:To explore the effects of edaravone on nerve function,serum D-dimer(D-D)and total bilirubin(TBil)levels in patients undergoing intracranial aneurysm clipping,and to analyze correlation between nerve function and serum D-D,TBil levels after treatment.Methods:Sixty patients who underwent intracranial aneurysm clipping from January 2018 to September 2019 were enrolled and divided into observation group and control group with the simple random grouping method,30 cases in each group.Both groups were given routine treatment of albumin,dopamine,low-molecular dextran,mannitol)for 10 days.On this basis,observation group was given edaravone for 14 days.NIHSS score,levels of serum D-D and TBil,and prognosis were compared between the two groups.Results:The NIHSS scores,D-D and TBil levels in the observation group before treatment and 14d after treatment were higher than those in control group(P<0.05).14d after treatment,serum D-D level was positively correlated with NIHSS score(r=0.426,P<0.05),while serum TBil level was negatively correlated with NIHSS score(r=-0.359,P<0.05).3 months after treatment,good rate of prognosis in observation group was higher than that in control group(70.00%vs 43.33%)(P<0.05).Conclusion:Edaravone treatment after intracranial aneurysm clipping can protect nerve function,which is related to changes in serum D-D and TBil levels.

关 键 词：颅内动脉瘤 颅内动脉瘤夹闭术 依达拉奉 神经功能 D-二聚体 总胆红素 

分 类 号：R74[医药卫生—神经病学与精神病学]