七叶皂苷钠联合阿替普酶静脉溶栓在急性脑梗死患者中的应用效果分析  

The application effect of sodium aescinate combined with alteplase intravenous thrombolysis in patients with acute cerebral infarction

作　　者：张坤 张学启[1] 朱静萍 胡文彬 童广安 ZHANG Kun;ZHANG Xue-qi;ZHU Jing-ping;HU Wen-bin;TONG Guang-an(The Third Ward of Neurology,Taihe County People's Hospital,Taihe 236600,China;The Second Ward,Department of Neurology,Affiliated Hospital of the Institute of Neurology,Anhui University of Traditional Chinese Medicine,Hefei 230061,China)

机构地区：[1]安徽省太和县人民医院神经内科三病区,安徽太和236600 [2]安徽中医药大学神经病学研究所附属医院神经内科二病区,安徽合肥230061

出　　处：《实用医院临床杂志》2020年第5期16-19,共4页Practical Journal of Clinical Medicine

基　　金：国家自然科学基金资助项目(编号81473535)。

摘　　要：目的探讨七叶皂苷钠联合阿替普酶静脉溶栓对急性脑梗死(ACI)患者的临床效果。方法90例ACI患者,按随机数字表法分为联合组和单一组各45例,单一组接受阿替普酶溶栓治疗,联合组接受七叶皂苷钠联合阿替普酶静脉溶栓治疗。比较两组临床疗效、氧化应激反应指标超氧化物歧化酶(SOD),硫代巴比妥酸法测定丙二醛(MDA),评估两组治疗前、治疗1周后、治疗1月后NIHSS得分、简明Fugl-Meyer量表得分、Barthel指数、日常生活能力量表(ADL),对比两组药物安全性。结果治疗后联合组总有效率高于对照组(P<0.05)。两组MDA、NIHSS评分降低,且联合组低于单一组;两组SOD、简明Fugl-Meyer量表评分、Barthel指数及ADL评分增高,且联合组高于单一组(P<0.05),两组不良反应发生率比较差异无统计学意义(P>0.05)。结论七叶皂苷钠联合阿替普酶静脉溶栓治疗可有效提高ACI患者的临床疗效,并且两者联合应用可有效改善患者神经功能、提高运动能力及生活能力,有一定安全性。Objective To investigate the clinical effect of sodium aescinate combined with alteplase in the treatment of patients with acute cerebral infarction(ACI).Methods Ninety patients with ACI were randomly divided into combination group and single group,45 in each group.The single group received alteplase thrombolysis,and the combined group received sodium aescinate combined with alteplase intravenous thrombolysis.The clinical efficacy and oxidative stress reaction indexes such as superoxide dismutase(SOD)and malondialdehyde(MDA)measured by thiobarbituric acid method were compared between the two groups.NIHSS score,concise fugl meyer scale score,Barthel index and activities of daily living scale(ADL)score of the two groups were evaluated before and after 1 week and 1 month of treatment.Results After treatment,the total effective rate of the combined group was significantly higher than that of the control group(P<0.05).After treatment,the scores of MDA and NIHSS in the two groups were significantly decreased,and the combined group was significantly lower than the single group.After treatment,SOD,concise fugl meyer scale score,Barthel index and ADL score of the two groups were significantly increased,and the combined group was significantly higher than the single group(P<0.05).The incidence of adverse reactions between the two groups had no statistically different(P>0.05).Conclusion Sodium aescinate combined with alteplase intravenous thrombolytic therapy can effectively improve the clinical efficacy of ACI patients,and the combination of the two can effectively improve the patient's neurological function,the motor ability and the living ability with certain safety.

关 键 词：七叶皂苷钠 阿替普酶 急性脑梗死 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]