基于QLICP-CE(V2.0)量表的宫颈癌患者生命质量及其与临床客观指标的典型相关分析  

Quality of life in patients with cervical cancer and their clinical objective indicators based on QLICP-CE(2.0):a canonical correlation analysis

作　　者：周佳丽 周琳 杨铮 万崇华 杨宏英[3] 陈焕伟[4] 孟琼 侯雪飞 ZHOU Jia-li;ZHOU Lin;YANG Zheng;WAN Chong-hua;YANG Hong-ying;CHEN Huan-wei;MENG Qiong;HOU Xue-fei(School of Public Health of Guangdong Medical University,Dongguan,Guangdong 523808,China;不详)

机构地区：[1]广东医科大学公共卫生学院,广东东莞523808 [2]广东医科大学人文与管理学院/生命质量与应用心理研究中心,广东东莞523808 [3]云南省肿瘤医院,云南昆明650106 [4]广东省农垦中心医院,广东湛江524002 [5]昆明医科大学公共卫生学院,云南昆明650500

出　　处：《现代预防医学》2020年第17期3243-3246,共4页Modern Preventive Medicine

基　　金：国家自然科学基金(71974040);广东省科技计划(2017A020215079);广东省基础与应用研究重大培育项目(2017KZDXM040、2018KTSCX074)。

摘　　要：目的分析宫颈癌患者生命质量与临床客观指标之间的关系。方法采用癌症患者生命质量测定量表体系之宫颈癌量表(QLICP-CEV2.0)对186名宫颈癌患者进行调查,采用典型相关分析来研究生命质量得分与其临床客观指标之间的关系。结果乳腺癌患者生命质量标准得分分别为:总量表(59.97±14.27),躯体功能领域(55.01±14.85),心理功能领域(55.55±16.61),社会功能领域(60.32±14.63),共性症状与副作用领域(64.76±21.03),特异模块领域(63.87±24.48)。典型相关分析显示有5对典型变量,其典型相关系数分别为r1=0.419、r2=0.401、r3=0.332、r4=0.292、r5=0.206,前四对P<0.05,前两对典型变量可解释60.742%的信息量。结论铁、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶/丙氨酸氨基转移酶、乳酸脱氢酶、中性粒细胞百分率、淋巴细胞百分率、单核细胞百分率、白/球蛋白与患者的生命质量具有较高的相关性,临床医生治疗时应予以重视,并综合多方面因素提高宫颈癌患者的生命质量。Objective To analyze the relationship between the quality of life in patients with cervical cancer and the clinical objective indicators.Methods A total of 186 patients with cervical cancer were investigated using the Quality of Life Instrument for Cancer Patients-Cervical Cancer(QLICP-CEV2.0),and the data were used to analyze the relationships of the clinical objective indicators with the QOL scores by canonical correlation analysis.Results The standardized scores of quality of life in patients with cervical cancer were 59.97±14.27 for the overall scale,and 55.01±14.85,55.55±16.61,60.32±14.63,64.76±21.03,63.87±24.48 for domains of physical function,psychological function,social function,common symptoms and side effects and the specific module,respectively.Five pairs of canonical variables were obtained through canonical correlation analysis,and the canonical coefficients were r1=0.419,r2=0.401,r3=0.332,r4=0.292,r5=0.206 with the first four pairs P<0.05.The two pairs of canonical variables could explain 60.742%of the amount of information(Variance).ConclusionThe levels of Fe,ALT,AST/ALT,LDH,LYMPHR,NEUTR,MONOR,A/G are strongly correlated with quality of life,to which clinicians should pay more attention in the treatment.And comprehensive factors should be considered to improve the quality of life in patients with cervical cancer.

关 键 词：宫颈癌 生命质量 临床客观指标 典型相关 

分 类 号：R737.[医药卫生—肿瘤]