甘露醇治疗早期脑出血对血肿扩大及预后的影响  

The Effect of Mannitol Treatment of Early Cerebral Hemorrhage on Hematoma Enlargement and Prognosis

作　　者：彭亮 PENG Liang(Department of Medical and Political Science,Dongli Hospital,Dongli District,Tianjin 300300,China)

机构地区：[1]天津市东丽区东丽医院医政科,天津300300

出　　处：《医学信息》2020年第17期155-156,共2页Journal of Medical Information

摘　　要：目的观察甘露醇治疗早期脑出血对血肿扩大及预后的影响。方法选取2018年2月~2019年2月在我院诊治的86例早期脑出血患者为研究对象,采用随机数字表法分为对照组和观察组,各43例。对照组于发病6 h内使用甘露醇治疗,观察组于发病6 h后使用甘露醇治疗,比较两组治疗总有效率、治疗前后认知功能MMSE评分、血肿扩大率、病死率及生活质量总评分。结果观察组临床治疗总有效率为93.02%,高于对照组的81.39%(P<0.05);治疗后两组MMSE评分均低于治疗前(P<0.05),但治疗后观察组与对照组比较(P>0.05);观察组血肿扩大率、病死率均低于对照组,治疗后生活质量总评分高于对照组(P<0.05)。结论过早给予早期脑出血患者甘露醇治疗,可能影响治疗效果,加重血肿扩大,影响患者预后。Objective To observe the effect of mannitol treatment of early cerebral hemorrhage on hematoma expansion and prognosis.Methods 86 patients with early cerebral hemorrhage who were diagnosed and treated in our hospital from February 2018 to February 2019 were selected as the research objects,and were divided into control group and observation group by random number table method,with 43 cases in each group.The control group was treated with mannitol within 6 h of onset,and the observation group was treated with mannitol within 6 h of onset.The total effective rate of treatment,cognitive function MMSE score before and after treatment,hematoma expansion rate,fatality rate and total quality of life were compared between the two groups.Results The total effective rate of clinical treatment in the observation group was 93.02%,which was higher than 81.39% in the control group(P<0.05);the MMSE scores of the two groups after treatment were lower than those before treatment(P<0.05),but the observation group was compared with the control group after treatment(P>0.05);the hematoma enlargement rate and fatality rate of the observation group were lower than those of the control group,and the total quality of life score after treatment was higher than that of the control group(P<0.05).Conclusion Premature administration of mannitol to patients with early cerebral hemorrhage might affect the therapeutic effect,aggravated hematoma enlargement,and affected the prognosis of patients.

关 键 词：甘露醇 早期脑出血 血肿 预后 

分 类 号：R743.34[医药卫生—神经病学与精神病学]