尼莫地平治疗脑室出血后脑血管痉挛的临床价值研究  

Clinical value of nimodipine in treatment of cerebral vasospasm after intraventricular hemorrhage

作　　者：胡斌[1] 胡稻[1] 曾多[1] 游涛[1] 叶世阳[1] 刘传金 肖世飞 Hu Bin;Hu Dao;Zeng Duo;You Tao;Ye Shiyang;Liu Chuanjin;Xiao Shifei(Department of Neurosurgery,Pingxiang People's Hospital,Pingxiang,Jiangxi,337000,China)

机构地区：[1]萍乡市人民医院神经外科,江西萍乡337000

出　　处：《当代医学》2020年第28期7-9,共3页Contemporary Medicine

基　　金：萍乡市科技局课题(2018PY007)。

摘　　要：目的探讨尼莫地平治疗脑室出血后脑血管痉挛的临床价值。方法选取2018年1月至2019年12月于本院就诊的60例脑室出血患者,按照随机数字表法分为两组,各30例。对照组给予常规基础治疗,观察组在对照组的基础上加用尼莫地平治疗。比较两组治疗2周后临床疗效、痉挛指数、炎性因子水平及不良反应情况。结果观察组总有效率为83.33%,高于对照组的60.00%,差异有统计学意义(P<0.05);治疗前,观察组与对照组炎性因子水平比较差异无统计学意义;观察组治疗7、14 d时痉挛指数分别为(4.01±0.42)、(2.13±0.15),低于对照组的(4.36±0.58)、(2.53±0.21),差异有统计学意义(P<0.05);观察组治疗后C-反应蛋白、降钙素原分别为(35.45±5.23)ng/L、(1.21±0.24)mg/L,低于对照组的(39.69±5.41)ng/L、(1.62±0.17)mg/L,差异有统计学意义(P<0.05);两组均未发生严重不良反应,且两组不良反应发生率比较差异无统计学意义。结论尼莫地平可增强脑室出血后脑血管痉挛治疗效果,改善痉挛指数,降低炎症反应,安全可靠。Objective To investigate the clinical value of nimodipine in treatment of cerebral vasospasm after intraventricular hemorrhage.Methods 60 patients with intraventricular hemorrhage who were treated in the hospital from January 2018 to December 2019 were divided into two groups according to random number table method,with 30 cases in each group.The control group was given routine basic treatment,while the observation group was treated with nimodipine based on the control group.The clinical efficacy,spasticity index,levels of inflammatory factors after treatment for 2 weeks,and the incidence of adverse reactions were compared betweet two groups.Results The total effective rate of the observation group was 83.33%,which was higher than 60.00%of the control group,with statistically significant difference(P<0.05);There was no statistically significant difference in the levels of inflammatory factors between the observation group and the control group before treatment.The spasticity index in the observation group[(4.01±0.42),(2.13±0.15)]after treatment for 7 d and 14 d were lower than that in the control group[(4.36±0.58),(2.53±0.21)],with statistically significant difference(P<0.05).The C-reactive protein and procalcitonin in the observation group[(35.45±5.23)ng/L,(1.21±0.24)mg/L]were lower than those in the control group[(39.69±5.41)ng/mL,(1.62±0.17)ng/L]after treatment,with statistically significant difference(P<0.05).There were no severe adverse reactions in the two groups,and the difference in the incidence of adverse reactions between the two groups was not statistically significant.Conclusion Nimodipine in treatment of cerebral vasospasm after intraventricular hemorrhage can enhance curative effects,improve spasticity index,and decrease inflammatory response,which is safe and reliable.

关 键 词：脑室出血 脑血管痉挛 尼莫地平 炎性因子 

分 类 号：R743.34[医药卫生—神经病学与精神病学]