奥氮平对脑梗死后失眠、焦虑、抑郁患者的疗效及日常生活能力影响的研究  

A Study on the Effect of Olanzapine on the Patients with Insomnia,Anxiety,Depression and Ability of Daily Life after cerebral Infarction

作　　者：李俊[1] 郑晓东[1] 漆琼瑶 易飞[1] LI Jun;ZHENG Xiaodong;QI Qiongyao;YI Fei(Department of Neurology,People’s Hospital of Pingxiang,Pingxiang 337005,China)

机构地区：[1]萍乡市人民医院神经内科,江西萍乡337005

出　　处：《中国医药指南》2020年第24期147-148,共2页Guide of China Medicine

摘　　要：目的探讨奥氮平治疗脑梗死后失眠、焦虑、抑郁患者的疗效及对其日常生活能力的影响。方法选取2017年1月至2019年1月我院收治的60例脑梗死后失眠、焦虑、抑郁的患者为研究对象,按随机数字法分为两组,每组30例。其中,未服用奥氮平的脑梗死后失眠、焦虑、抑郁患者30例为对照组,给予奥氮平治疗2周后的脑梗死后失眠、焦虑、抑郁患者30例为试验组,运用汉密尔顿焦虑量表评分(HAMA)、汉密尔顿抑郁量表(HAMD)17项评分和匹兹堡睡眠质量指数(PSQI)及各因子的评分及日常生活能力(Barthel指数评分)比较试验组与对照组间的差异。结果①试验组PSQI及各因子的评分在主观睡眠质量、睡眠潜伏期、睡眠持续性、睡眠效率、睡眠紊乱、日间功能评分高于对照组,比较差异具有统计学意义(P <0.05)。②试验组的HAMA、HAMD评分均低于对照组,Barthel指数评分低于对照组,比较差异有统计学意义(P <0.01)。结论奥氮平可以改善脑梗死后失眠症状,同时也改善脑梗死患者焦虑、抑郁症状,提高日常生活能力,不良反应少、安全性高。Objective To explore the therapeutic effect of olanzapine on insomnia,anxiety and depression and the ability of daily life after cerebral infarction.Methods Sixty patients with insomnia,anxiety,and depression after cerebral infarction in our hospital from January 2017 to January 2019 were selected as the research objects.Divided into two groups of 30 cases by random number method.30 patients with insomnia,anxiety and depression after cerebral infarction without olanzapine were used as control group.Patients with insomnia,anxiety,depression after cerebral infarction were given olanzapine for 2 weeks as the experimental group.Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD)17 items,Pittsburgh Sleep Quality Index(PSQI),the scores of each factor and the ability of daily living(Barthel Index)were used,compare the diff erence between the experimental group and the control group before and after treatment.Results The scores of PSQI and each factor in the experimental group were lower than the control group in subjective sleep quality,sleep latency,sleep persistence,sleep effi ciency,sleep disturbance,and daytime function scores.The diff erence were statistically signifi cant(P<0.05).The experimental group had lower HAMA and HAMD scores than the control group;Barthel Index score higher than control group.The difference were statistically signifi cant(P<0.01).Conclusion Olanzapine can improve the symptoms of insomnia after cerebral infarction,and also improve the symptoms of anxiety and depression in patients with cerebral infarction,improve the ability of daily living,less adverse reactions and high safety.

关 键 词：脑梗死 奥氮平 失眠 焦虑 抑郁 疗效 日常生活能力 

分 类 号：R743.33[医药卫生—神经病学与精神病学]