Early-life nutrition and metabolic disorders in later life:a new perspective on energy metabolism  

作　　者：Li-Yuan Zhou Ming-Qun Deng Qian Zhang Xin-Hua Xiao 

机构地区：[1]Key Laboratory of Endocrinology of National Health Commission,Department of Endocrinology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,Beijing 100730,China

出　　处：《Chinese Medical Journal》2020年第16期1961-1970,共10页中华医学杂志（英文版）

基　　金：Supported by the grants from the National Natural Science Foundation of China(Nos.81870579,81870545,81170736,81570715).

摘　　要：Type 2 diabetes mellitus and metabolic disorders have become an epidemic globally.However,the pathogenesis remains largely unclear and the prevention and treatment are still limited.In addition to environmental factors during adulthood,early life is the critical developmental window with high tissue plasticity,which might be modified by external environmental cues.Substantial evidence has demonstrated the vital role of early-life nutrition in programming the metabolic disorders in later life.In this review,we aim to overview the concepts of fetal programming and investigate the effects of early-life nutrition on energy metabolism in later life and the potential epigenetic mechanism.The related studies published on PubMed database up to March 2020 were included.The results showed that both maternal overnutrition and undernutrition increased the riskes of metabolic disorders in offspring and epigenetic modifications,including DNA methylation,miRNAs,and histone modification,might be the vital mediators.The beneficial effects of early-life lifestyle modifications as well as dietary and nutritional interventions on these deleterious metabolic remolding were initially observed.Overall,characterizing the early-life malnutrition that reshapes metabolic disease trajectories may yield novel targets for early prevention and intervention and provide a new point of view to the energy metabolism.

关 键 词：Early-life nutrition Energy metabolism EPIGENETICS In later life 

分 类 号：R589[医药卫生—内分泌] R587.1[医药卫生—内科学]