A novel mouse model of hyperuricemia and gouty nephropathy  

作　　者：Jin Guan Xiao-Qi Huang Jia-Le Dong Hui-Min Lu Yue-Wei Lin Mei Liu Zhi-Biao Yi Li-Min Wu Yong-Ming Huang Tian Lan 

机构地区：[1]Department of Pharmacology,School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China [2]Guangzhou University of Chinese Medicine,Math Engineering Academic Chinese Medicine,Guangdong Province of Key Lab New Drug Dev&Res Chinese,Guangzhou,Guangdong 510006,China [3]Guangzhou University of Chinese Medicine,Dongguan Math Engineering Academic Chinese Medicine,Dongguan,Guangdong 523808,China [4]Foshan Santanyi Biotech Co.,Ltd,Foshan,Guangdong 528031,China [5]Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,Guangdong 510006,China

出　　处：《Chinese Medical Journal》2020年第16期2012-2014,共3页中华医学杂志（英文版）

基　　金：Supported by grants from the Science and Technology Planning Project of Guangdong Province(No.2017A020211007),China;the Key Project of Natural Science Foundation of Guangdong Province(No.2016A030311014),China;the National Natural Science Foundation of China(No.81870420);Special Project on the Integration of Industry,Education and Research of Guangdong Province(No.2014B090902002);Science and Technological Program for Dongguan’s Social Development(No.2016108101043).

摘　　要：To the Editor:Hyperuricemia,the second most common metabolic disease after diabetes mellitus in China,is characterized by the elevated serum uric concentration which is due to the overactive uric acid production or underexcretion.[1]Recent study supported the notion that hyperuricemia is implicated in renal tubular injury,subsequent tubulointerstitial fibrosis,and finally gouty nephropathy.[2]However,the lack of a suitable and stable mouse model to study hyperuricemia and gout nephropathy delays and limits the development of mechanism research and new drugs.Further understanding of the pathogenesis of hyperuricemia and gouty nephropathy has been largely hampered by a lack of preclinical animal models that reliably capture the characteristic phenotypes of hyperuricemia and gouty nephropathy.In this study,we aimed to develop a novel mouse model for hyperuricemia and gouty nephropathy.

关 键 词：NEPHROPATHY ELEVATED DRUGS 

分 类 号：R589.7[医药卫生—内分泌] R-332[医药卫生—内科学]