白介素9在炎症性肠病中的作用  

Role of interleukin 9 in inflammatory bowel disease

作　　者：张方 董月美 赵美华[1] 马娜[1] 张目涵 王斌斌 冯百岁[1] Zhang Fang;Dong Yuemei;Zhao Meihua;Ma Na;Zhang Muhan;Wang Binbin;Feng Baisui(Department of Gastroenterology,The Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014,China)

机构地区：[1]郑州大学第二附属医院消化内科,450014

出　　处：《中华炎性肠病杂志（中英文）》2020年第3期262-265,共4页Chinese Journal of Inflammatory Bowel Diseases

基　　金：郑州大学前沿交叉研究专项项目(32410243);河南省医学科技攻关计划省部共建项目(SBGJ2018042);河南省医学科技攻关计划联合共建项目(2018020164);河南省卫生计生科技创新型人才特聘学科带头人(豫卫科〔2016〕32号);河南省自然科学基金项目(162300410268)。

摘　　要：白介素(IL)-9由极性状态的Th2细胞分泌,其表达受到多种信号因子的调节,与细胞因子微环境密切相关。IL-9与自身免疫性疾病、变态反应性疾病等密切相关。炎症性肠病(IBD)是一种病因尚不明确的肠道非特异性慢性炎症性疾病。研究发现肠黏膜免疫平衡失调与其发病密切相关,IL-9通过调节紧密连接相关蛋白的表达影响肠黏膜的屏障功能,从而参与IBD的病理生理过程。本文对IL-9在IBD中的作用进行综述。Interleukin 9(IL-9)is secreted by polar Th2 cells and its expression is regulated by a variety of signaling factors,which is closely related to cytokine microenvironment,autoimmune diseases and allergic diseases.Inflammatory bowel disease(IBD)is a kind of intestinal nonspecific chronic inflammatory intestinal disease with uncertain etiology.It has been found that the immune imbalance of intestinal mucosa is closely related to its pathogenesis.IL-9 is involved in the pathophysiological process of IBD by regulating the expressions of tight junction associated proteins and affecting the barrier function of intestinal mucosa.This review presents the role of IL-9 in IBD.

关 键 词：炎症性肠病 白介素9 紧密连接 

分 类 号：R574[医药卫生—消化系统]