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作 者:Jing Tang Bowei Zhou Melanie J.Scott Linsong Chen Dengming Lai Erica K.Fan Yuehua Li Qiang Wu Timothy R.Billiar Mark A.Wilson Ping Wang Jie Fan
机构地区:[1]The Department of Anesthesiology,Affiliated hospital of Guangdong Medical University,Zhanjiang 524000,China [2]Department of Surgery,University of Pittsburgh School of Medicine,Pittsburgh,PA 15213,USA [3]Research and Development,Veterans Affairs Pittsburgh Healthcare System,Pittsburgh,PA 15240,USA [4]Department of Anesthesiology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China [5]Department of Thoracic Surgery,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai 200433,China [6]Department of Cardiovascular Surgery,The Children's Hospital of Zhejiang University School of Medicine,Hangzhou 310052,China [7]University of Pittsburgh The Graduate School of Public Health,Pittsburgh,PA 15213,USA [8]Laboratory of Tropical Biomedicine and Biotechnology,School of Tropical Medicine and Laboratory Medicine,Hainan Medical University,Haikou 571199,China [9]The Feinstein Institute for Medical Research,Manhasset,NY 11030,USA [10]McGowan Institute for Regenerative Medicine,University of Pittsburgh,Pittsburgh,PA 15219,USA [11]Key Laboratory of Organ Injury/Protection and Translational Medicine of Zhanjiang,Zhanjiang 524000,China
出 处:《Protein & Cell》2020年第8期618-619,共2页蛋白质与细胞(英文版)
摘 要:Figure 1.EGFR activation promotes TLR4 phosphorylation and cell surface expression of TLR4 in response to LPS.(A and B)BMDM were treated with LPS(1μg/mL)for 6,12,or 24 h in the presence or absence of pretreatment of PD or TAPI-1.(A)Flow cytometry analysis of cell surface TLR4 intensity in BMDM.(B)Flow cytometry analysis of cell surface TLR4 intensity in BMDM.(C and D)WT(C57BL76)mice were treated with LPS(10 mg/kg,i.p.).In some groups,mice were pretreated with erlotinib(100 mg/kg,gavage administration)at 30 min prior to LPS i.p.
关 键 词:ACTIVATION surface PHOSPHORYLATION
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