Facile Synthesis of High Molecular Weight Polypeptides via Fast and Moisture Insensitive Polymerization of a-Amino Acid N-Carboxyanhydrides  

作　　者：Yue Ming Wu Wei-Wei Zhang Rui-Yi Zhou Qi Chen Chen-Yu Xie Heng-Xue Xiang Bin Sun Mei-Fang Zhu Run-Hui Liu 

机构地区：[1]State KeyLaboratory of Bioreactor Enginering,East China Uniersity of Science and Technology,Shanghai 200237,China [2]State Key Laboratory for Modification of Chemical Fibers and Polymer Materals,College of Materias Science and Enginering,Donghua University,Shanghai 201620,China [3]Key Laboratory of Specally Functional Polymeric Materials and Related Technology(ECUST)Ministry of Education,Key Laboratory for Ultrafine Materials of Ministry of Education,Research Center for Biomedical Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China

出　　处：《Chinese Journal of Polymer Science》2020年第10期1131-1140,I0007,共11页高分子科学（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China(Nos.21774031 and 21861162010);the National Key Research and Development Program of China(No.2016YFC1100401);Research Program of State Key Laboratory of Bioreactor Enginering,State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua University,the Fundamental Research Funds for the Central Universities(Nos.22221818014 and 50321041917001);The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

摘　　要：Polypeptides have been widely utilized in the fields of biomaterials and biomedicine.Ever since N-carboxyanhydride(NCA)was reported by Hermann Leuchs in 1906,ring-opening polymerization of NCAS has been extensively used to prepare polypeptides.Despite continuous innovations,it is still challenging to synthesize polypeptides in high molecular weight fficiently.To address this challenge,we developed KHMDS/NaHMDS initiated fast NCA polymerization that is also moisture tolerant,open-flask amenable and terminal tunable.This NCA polymerization was able to proceed in most common solvents and meet the solubility requirement of variable NCA monomers and corresponding polypeptides.KHMDS can initiate r benzy-L glutamate-N carboxyanhydride(BLG NCA)polymerization in a reaction rate 92 times faster than does hexylamine and 80 times faster than does triethylamine.This NCA polymerization also demonstrated easy and fast synthesis of gram-scale long chain polypeptides in an open flask.

关 键 词：NCA polymerization POLYPEPTIDE Open vessel Fast polymerization High Mw 

分 类 号：TQ317[化学工程—高聚物工业]