伴关节炎的老年溃疡性结肠炎患者黏膜组织中环氧化酶-2和肿瘤坏死因子-α的表达及其意义  

Expression and its clinical significance of cydooxygenase-2 and tumor necrosis factor-alpha in mucosal tissues in elderly ulcerative colitis patients with arthritis

作　　者：郭婧 李璐[2] 王兆辉 徐德亮[1] Guo Jing;Li Lu;Wang Zhaohui;Xu Deliang(Department of Digestive Medicine.Zaozhuang Municipal Hospital,Zaozhuang 277100,China;Department of Rheumatology and Im m unology,Zaozhuang Municipal Hospital,Zaozhuang 277100,China;Depariment of Pathology,Zaozhuang Municipal Hospital,Zaozhuang 277100,China)

机构地区：[1]枣庄市立医院消化内科,277100 [2]枣庄市立医院风湿免疫科,277100 [3]枣庄市立医院病理科,277100

出　　处：《中华老年医学杂志》2020年第9期1055-1058,共4页Chinese Journal of Geriatrics

摘　　要：目的探讨伴关节炎的老年溃疡性结肠炎(UC)患者黏膜组织中环氧化酶-2(COX-2)和肿瘤坏死因子-α(TNF-α)的表达及其意义。方法选取2016年4月至2019年3月我院收治的伴关节炎的活动期UC患者164例(观察组),另外选取同期活动期UC(非合并关节炎)患者50例为对照组,检测两组患者黏膜组织中COX-2和TNF-α的表达,并进行比较。将观察组患者分别根据溃疡病变的严重程度、Kellgren-Lawrence(K-L)分级进行分组,比较溃疡病变不同严重程度、不同K-L分级患者黏膜组织中COX-2和TNF-α的表达。结果观察组患者黏膜组织中COX-2、TNF-α的表达高于对照组(P<0.05);溃疡性结肠炎患者病情加重和K-L分级增加,黏膜组织中COX-2、TNF-α的表达均明显增加(P<0.05),且溃疡病情不同严重程度患者、不同K-L分级患者组间差异均具有统计学意义(P<0.05);伴关节炎溃疡性结肠炎患者黏膜组织中COX-2、TNF-α的表达与溃疡病情严重程度呈正相关(r值分别为0.491、0.627,P<0.05或P<0.01),与关节炎病变K-L分级呈正相关(r值分别为0.438、0.597,P<0.05或P<0.01)。结论伴关节炎的老年溃疡性结肠炎患者黏膜组织中COX-2和TNF-α的表达与溃疡严重程度、K-L分级均呈正相关,检测二者水平有助于病情严重程度的评估。Objective.To investigate the expression and its clinical significance of cydooxygenase-2(COX-2)and tumor necrosis factor alpha(TNF-a)in mucosal tissues in elderly ulcerative colitis(UC)patients with arthritis.Methods A total of 164 active(observation group)and 50 non-active(control group)UC patients with arthritis were admitted in our hospital from April 2016 to March 2019.Diagnostic criteria of UC and its severity were based on Consensus on the Norms for Diagnosis and Treatment of Inflammatory Bowel Disease in China(2007).The expressions of COX-2 and TNF-alpha in mucosal tissues were detected and compared between the two groups.Patients in the observation group were re grouped according to the severity of ulcer lesion and Kellgren-Lawrence(K-L)score of arthritis.Based on severity of ulcer lesion and Kellgren-Lawrence(K-L)score of arthritis,the patients in observation group were re grouped intoI,II,II,IV subgroups,among those subgroups the expressions of COX-2 and TNF-alpha in mucosal tissues were compared.Results The expressions of COX-2 and TNF-alpha in mucosal tissue were higher in the observation group than in the control group(P<0.05).and were increased along with the increased severity of UC and the K-Lgrade of arthritis(P<0.05).The differences in above expressions had statistical significance among patients with different severity of ulcer and different K-L grade of arthritis.The expresvsions of COX-2 and TNF-alpha in mucosal tissues were positively correlated with the severity of ulcer(r=0.491 and 0.627<C 0.05 or 0.01)and K-L grade of arthritis(r=0.438 and 0.597,P<0.05 or 0.01).Conclusions The expressions of COX-2 and TNF-alpha in mucosal tissues are positively correlated with the severity of ulcer and K-Lgrade of arthritis in elderly UC patients with arthritis.The detection of COX-2 and TNF-alpha levels is helpful to evaluate the disease severity.

关 键 词：结肠炎 溃疡性 关节炎 环氧化酶2 肿瘤坏死因子-Α 

分 类 号：R574.62[医药卫生—消化系统] R684.3[医药卫生—内科学]