Synthesis, Crystal Structure and Antibacterial Activity of New N-(1H-benzo[d]imidazol-2-yl)benzenesulfonamide Derivatives of Dehydroabietic Acid  

作　　者：CAI Xu-Min LI A-Liang LIN Yu-Ting WANG Wen-Yan WANG Shi-Fa GU Wen 蔡旭敏;李阿良;蔺玉婷;王文燕;王石发;谷文(Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass,Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals,College of Chemical Engineering,Nanjing Forestry University,Nanjing 210037,China)

机构地区：[1]Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass,Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals,College of Chemical Engineering,Nanjing Forestry University,Nanjing 210037,China

出　　处：《Chinese Journal of Structural Chemistry》2020年第8期1539-1545,1362,共8页结构化学（英文）

基　　金：supported by the National Natural Science Foundation of China(31770616 and 21601087);the Natural Science Foundation for Colleges and Universities in Jiangsu Province(17KJA220002);Top-notch Academic Programs Project of Jiangsu Higher Education Institutions(PPZY2015C221)。

摘　　要：The title compounds(7a^7g)were synthesized from dehydroabietic acid and characterized by spectroscopic methods including HR-MS,1H-and 13C-NMR.The crystal structure of compound 7g determined by single-crystal X-ray diffractio is of monoclinic system,space group P21 with a=12.282(3),b=9.940(2),c=22.656(5)A,β=103.06(3)°,Z=2,V=2694.4(10)A^3,Mr=1182.95,Dc=1.458 Mg/m^3,S=1.000,μ=1.649 mm^-1,F(000)=1216,the final R=0.0791 and wR=0.1853 for 4098 observed reflections(Ⅰ>2σ(Ⅰ)).The preliminary antibacterial assay showed that compound 7g exhibits significant inhibitory against Bacillus subtilis,Staphylococcus aureus and Methicillin-resistant S.aureus(MRSA)with MIC values of 1.9~7.8μg/mL.

关 键 词：dehydroabietic acid BENZIMIDAZOLE SULFONAMIDE crystal structure antibacterial activity 

分 类 号：O626[理学—有机化学]