BENZIMIDAZOLE

作品数:151被引量:151H指数:5
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相关领域:理学更多>>
相关作者:林伟聪郑晓杰郑康成吴文娟张林更多>>
相关机构:广东药科大学中山大学国立中兴大学武汉工程大学更多>>
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相关基金:国家自然科学基金广东省自然科学基金国家教育部博士点基金重庆市自然科学基金更多>>
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Visible-light-induced radical-cascade alkylation/cyclization of N-methacryloyl-2-phenylbenzimidazole:Access to benzoimidazo[2,1-a]isoquinolin-6(5H)-ones
《Green Synthesis and Catalysis》2024年第4期319-323,共5页Yanhong Wang Xinlei Zhou Tao Zhang Xinxin Ren Wei Xu Bin Wang Weiwei Jin Yu Xia Chenjiang Liu Yonghong Zhang 
supported by the Natural Science Foundation of Xinjiang Uyghur Autonomous Region(Nos.2022E01042,2022TSYCCX0024,and 2021D01E10);the NSFC(Nos.21861036,21961037 and 21762041).
A metal-free visible-light-induced synthesis of aza-polycyclic aromatic hydrocarbons via cascade alkylation/cyclization of N-methacryloyl-2-phenylbenzimidazole was developed.The reaction was carried out with inactive ...
关键词:Visible light catalysis PHENANTHRENEQUINONE Benzimidazole[2 1-a]isoquinoline-6(5H)-ones Radical cascade reactions Hydrogen atom transfer(HAT) 
Enantioselective Synthesis of Benzimidazole Atropisomers Featuring a N-N Axis
《Chinese Journal of Chemistry》2024年第7期711-718,共8页Fang-Bei Ge Qi-Kun Yin Chuan-Jun Lu Xuan Xuan Jia Feng Ren-Rong Liu 
supported by Taishan Scholar Youth Expert Program in Shandong Province (tsqn201909096);National Natural Science Foundation of China (22371152);Shandong Provincial Natural Science Foundation Project (ZR2023JQ006,ZR2022MB021);the startup fund from Qingdao University.
Atroposelective synthesis of N-N atropisomers is an emerging area but remains underexplored;in particular,the synthesis of N-N benzimidazole atropisomers is still unprecedented.Herein,the first enantioselective synthe...
关键词:Asymmetric synthesis ATROPISOMERISM PALLADIUM BENZIMIDAZOLE ANTITUMOR 
Modification strategies for non-aqueous, highly proton-conductive benzimidazole-based high-temperature proton exchange membranes
《Chinese Chemical Letters》2024年第4期43-51,共9页Yunfa Dong Shijie Zhong Yuhui He Zhezhi Liu Shengyu Zhou Qun Li Yashuai Pang Haodong Xie Yuanpeng Ji Yuanpeng Liu Jiecai Han Weidong He 
supported by the Science Foundation of National Key Laboratory of Science and Technology on Advanced Composites in Special Environments;the National Natural Science Foundation of China (No.12002109);sponsored by Natural Science Foundation of Chongqing, China (Nos.CSTC2021jcyj-msxm X10305, CSTB2022NSCQMSX0246, CSTB2022NSCQ-MSX0242, CSTB2022NSCQMSX1244, CSTB2022NSCQ-MSX0441, CSTB2022NSCQMSX1356, CSTB2022NSCQ-MSX1572, CSTB2022NSCQ-MSX1583, CSTB2022NSCQ-MSX0487, CSTB2022TFII-OFX0034);Chongqing Technology Innovation and Application Development Special Key Project (No.CSTB2023TIAD-KPX0010)。
High-temperature proton exchange membranes(HT-PEMs) possess excellent thermal and outstanding electrochemical stability, providing an avenue to realize high-temperature proton exchange membranes fuel cells(HT-PEMFCs) ...
关键词:BENZIMIDAZOLE Nonaqueous proton conduction Free volume Nanophase-separated structure Structure modification 
Rh(III)-catalyzed [5+1] spirocyclization to produce novel benzimidazole-incorporated spirosuccinimides
《Green Synthesis and Catalysis》2023年第4期338-341,共4页Wei-Yi Pu Xin-Yi Chen Lin Dong 
We are grateful for the financial support from 111 Project(No.B18035)and“the Fundamental Research Funds for the Central Universities”.
Transition-metal-catalyzed cross-coupling reactions as very efficient and atom-economical approaches have been widely used to build up complex heterocyclic compounds.However,modification of 2-oxyl benzimidazole skelet...
关键词:Rh(III)-catalysis 2-Oxyl benzimidazole MALEIMIDES SPIROCYCLIZATION 
BZD9L1 benzimidazole analogue hampers colorectal tumor progression by impeding angiogenesis被引量:1
《World Journal of Gastrointestinal Oncology》2023年第5期810-827,共18页Chern Ein Oon Ayappa V Subramaniam Lik Yang Ooi Ashwaq Hamid Salem Yehya Yeuan Ting Lee Gurjeet Kaur Sreenivasan Sasidharan Beiying Qiu Xiaomeng Wang 
Supported by the Ministry of Higher Education Malaysia for the Fundamental Research Grant Scheme,No. FRGS/1/2021/SKK06/USM/02/7
BACKGROUND The development of new vasculatures(angiogenesis)is indispensable in supplying oxygen and nutrients to fuel tumor growth.Epigenetic dysregulation in the tumor vasculature is critical to colorectal cancer(CR...
关键词:Colorectal cancer BZD9L1 SIRTUIN BENZIMIDAZOLE ANGIOGENESIS 
Benzimidazole and its derivatives as cancer therapeutics:The potential role from traditional to precision medicine
《Acta Pharmaceutica Sinica B》2023年第2期478-497,共20页Yeuan Ting Lee Yi Jer Tan Chern Ein Oon 
the Ministry of Higher Education Malaysia for the Fundamental Research Grant Scheme with the Project Code:FRGS/1/2021/SKK06/USM/02/7 for supporting this work。
Cancer is the second leading cause of mortality globally which remains a continuing threat to human health today.Drug insensitivity and resistance are critical hurdles in cancer treatment;therefore,the development of ...
关键词:Benzimidazole derivatives Targeted therapy ANTICANCER Precision medicine 
A New Discovery towards Novel Skeleton of Benzimidazole-Conjugated Pyrimidinones as Unique Effective Antibacterial Agents被引量:2
《Chinese Journal of Chemistry》2022年第22期2642-2654,共13页Xi Yang Rasheed Syed Bo Fang Cheng-He Zhou 
supported by grants from the National Natural Science Foundation of China(No.21971212);the Research Fellowship for International Young Scientists from International(Regional)-Cooperation and Exchange Program of China National Natural ScienceFoundation(No.81350110523);theKey Project of Innovation Research 2035Pilot Plan of Southwest University(SWU-XDZD22007).
A class of new potential antibacterial agents with distinctive pyrimidinone benzimidazole skeleton was developed through nucleophilic substitution and Biginelli reaction starting from urea,ethyl 4-chloroacetoacetate a...
关键词:PYRIMIDINONE BENZIMIDAZOLE Antibacterial Resistance Membrane 
Drug flibanserin–in hypoactive sexual desire disorder
《Gynecology and Obstetrics Clinical Medicine》2022年第2期91-95,共5页Pugazhenthan Thangaraju Hemasri Velmurugan Sree Sudha TY 
Hypoactive sexual desire disorder(HSDD)is a widely known type of female sexual dysfunction that could also cause emotional distress and relationship problems.Flibanserin,a benzimidazole,was being studied as a treatmen...
关键词:FLIBANSERIN BENZIMIDAZOLE Food and drug administration Premenopausal women EFFICACY SAFETY Hypoactive sexual desire disorder 
Quantitative Structure-Activity Relationship Study of a Benzimidazole-Derived Series Inhibiting Mycobacterium tuberculosis H37Rv
《Computational Chemistry》2022年第2期71-96,共26页Georges Stéphane Dembélé Mamadou Guy-Richard Koné Fandia Konate Doh Soro Nahossé Ziao 
This work was carried out on a series of twenty-two (22) benzimidazole derivatives with inhibitory activities against Mycobacterium tuberculosis H37Rv by applying the Quantitative Structure-Activity Relationship (QSAR...
关键词:Mycobacterium tuberculosis H37Rv Benzimidazole Derivatives QSAR ANN Applicability Domain 
Syntheses,Crystal Structures and DNA-Binding Properties of Zn(Ⅱ)and Mn(Ⅱ)Complexes Based on Imidazole Derivatives and Carboxylic Acid
《Chinese Journal of Structural Chemistry》2022年第3期260-269,I0014,共11页GUAN Hui-Chao SONG Xiao-Tong LIU Gui-Bao YUE Shu-Mei 
Complexes[Zn(pbm)(5-hip)_(3)](1),[Zn(pbm)(5-nip)3](2),[Mn(pbm)(H_(3)btc)_(2)(H_(2)O)](3)and[Mn(pbm)(5-nip)_(3)](4),where H2HIPA=5-hydroxyisophthalic acid,H2nip=5-nitroisophthalic acid,H3btc=tri-mesic acid and pbm(pyri...
关键词:single-crystal structures spectroscopy CT-DNA binding 2-(2-pyridyl)benzimidazole 
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