云南高校图书馆联盟文献共享服务平台- SIRTUIN

SIRTUIN: 作品数：232被引量：775H指数：13; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：朱钦士何彬李勇军李燕王永林更多>>; 相关机构：东南大学上海交通大学西特里斯药业公司华中科技大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>

Zishen Huoxue decoction(ZSHX)alleviates ischemic myocardial injury(MI)via Sirt5-β-tubulin mediated synergistic mechanism of"mitophagy-unfolded protein response"and mitophagy: 《Chinese Journal of Natural Medicines》2025年第3期311-321,共11页Xing Chang Siyuan Zhou Yu Huang Jinfeng Liu Yanli Wang Xuanke Guan Qiaomin Wu Zhiming Liu Ruxiu Liu; supported by the National Natural Science Foundation of China(No.82305204),the Special Project on Academic Inheritance and Communication,China Academy of Chinese Medical Sciences(No.CI2022E012XB);Chinese Academy of Chinese Medical Sciences Doctoral Talents Training Fund(No.2021);the Special Program for Training Outstanding Young Talents of Chinese Academy of Traditional Chinese Medicine(No.ZZ16-YQ-021);the Innovative Cultivation Project of Guang'anmen Hospital,Chinese Academy of Chinese Medical Sciences(No.2022s481).; Zishen Huoxue decoction(ZSHX)enhances cardiomyocyte viability following hypoxic stress;however,its upstream therapeutic targets remain unclear.Network pharmacology and RNA sequencing analyses revealed that ZSHX target...; 关键词：MITOPHAGY Mitochondrial unfolded protein response Zishen Huoxue decoction Sirtuin 5 Β-TUBULIN Mitochondrial oxidative stress

Context-dependent role of sirtuin 2 in inflammation被引量：1: 《Neural Regeneration Research》2025年第3期682-694,共13页NoemíSola-Sevilla Maider Garmendia-Berges MCarmen Mera-Delgado Elena Puerta; funded by FEDER/Ministerio de Ciencia,Innovación y Universidades Agencia Estatal de Investigación/Project(PID2020-119729GB-100,REF/AEI/10.13039/501100011033)(to EP);a predoctoral fellowship from the Spanish Ministry of Universities(FPU)and Amigos de la Universidad de Navarra(to NSS);“Programa MRR Investigo 2023”(to MGB and MMD)。; Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has...; 关键词：INTERFERON INFLAMMATION LIPOPOLYSACCHARIDE NEUROINFLAMMATION NLRP3 nuclear factorκB sirtuin 2

凉血消风汤对HaCaT细胞中组蛋白H4乙酰化及其相关酶的干预机制研究: 《新中医》2025年第5期202-208,共7页王文欢王亚翠贾瑞璇王红梅; 大连市医学科学研究计划项目(21Z11024)。; 目的:研究凉血消风汤对人永生化角质形成细胞(HaCaT)中组蛋白H4乙酰化(Acetyl-Histone H4)及组蛋白乙酰基转移酶1(HAT1)、乙酰化转移酶P300、去乙酰化酶sirtuin(SIRT)3、SIRT5的干预作用,进而探讨乙酰化修饰参与银屑病发病的作用机制。...; 关键词：银屑病凉血消风汤人永生化角质形成细胞组蛋白乙酰基转移酶1 乙酰化酶P300 去乙酰化酶sirtuin 3 去乙酰化酶sirtuin 5

间充质干细胞通过调控Sirt1改善代谢相关脂肪性肝病的机制研究进展: 《右江医学》2025年第2期173-177,共5页李其龙高建鹏; 深圳市科技攻关项目(202247);深圳市科技创新项目(JCYJ20220530163602006);云南省卫生和计划生育委员会医学领军人才培养计划(L-2017008)。; 代谢相关脂肪性肝病(metabolic associated fatty liver disease,MAFLD)现已成为最常见的慢性肝病,给世界公共卫生带来沉重的负担^([1])。根据美国国家卫生与临床优化研究所(NICE)^([2])、欧洲肝脏研究协会(EASL)、欧洲糖尿病研究协会(E...; 关键词：代谢性脂肪性肝病间充质干细胞氧化应激 Sirtuin 1蛋白

Transcriptome and single-cell profiling of the mechanism of diabetic kidney disease: 《World Journal of Diabetes》2025年第2期216-236,共21页Ying Zhou Xiao Fang Lin-Jing Huang Pei-Wen Wu; Joint Funds for the Innovation of Science and Technology,Fujian Province,No.2021Y9106;Fujian Provincial Health Technology Project,No.2021GGA033;the Natural Science Foundation of Fujian Province,No.2024J011234.; BACKGROUND The NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome may play an important role in diabetic kidney disease(DKD).However,the exact link remains unclear.AIM To investigate the ...; 关键词：Diabetic kidney disease Single-cell RNA sequencing analysis NOD-like receptor thermal protein domain associated protein 3 Sirtuin 2 Caspase 1

虾青素对13月龄罗曼粉蛋鸡卵巢组织结构和Sirtuin基因家族表达的影响: 《家禽科学》2024年第12期5-11,I0012,共8页彭雅洁莫小川袁翠李方波吴江康恺; 广东省自然科学基金项目(2020A1515110362);广东省创新强校基金项目(2020KZDZX1110);湛江市科学技术局海洋生物方向基金项目(2021E05028);广东海洋大学大学生创新训练项目(S202310566023,S202210566037,S202110566028)。; 卵巢是影响蛋鸡产蛋性能的重要器官,产蛋期卵巢生理机能衰退会导致产蛋率下降。本文旨在研究不同水平虾青素对13月龄罗曼粉蛋鸡卵巢组织和Sirtuin基因家族表达的影响。选取16只健康、体重相近的13月龄罗曼粉蛋鸡,随机分为4组,每组4个重...; 关键词：虾青素卵巢 SIRTUIN 蛋鸡

2-hydroxy-3-methyl anthraquinone promotes apoptosis and inhibits invasion of human hepatocellular carcinoma cells by targeting nicotinamide adenine dinucleotide-dependent protein deacetylase sirtuin-1/cellular tumor antigen p53 signaling pathway: 《Journal of Traditional Chinese Medicine》2024年第6期1104-1110,共7页WU Shuang LI Qiao ZHU Xieying ZHANG Taoyuan; Natural Science Basic Research Plan in Shannxi Province of China,the Intervention and Mechanism of Developmentalendotheliallocus-1 Regulating Macrophage Efferocytosis on Airway Inflammation in Chronic Obstructive Pulmonary Disease (No. 2020JQ-543);the Function and Mechanism of New Tumor Suppressor TSC22D2 in Cancer Glycometabolism (No. 2020JQ-927);Fundamental Research Funds for The Central University:the Role of TSC22D2-centered Protein Interaction Map in Cancer Glycometabolism and Cell Growth (No. xzy012019129)。; OBJECTIVE: To investigate the anti-liver cancer effect of 2-hydroxy-3-methyl anthraquinone(HMA) and the specific mechanism based on nicotinamide adenine dinucleotidedependent protein deacetylase sirtuin-1(SIRT1)/cellu...; 关键词：2-hydroxy-3-methylanthraquinone carcinoma hepatocellular apoptosis INVASION sirtuin 1 genes p53

基于SIRT1探索中医药防治慢性阻塞性肺疾病的研究现状: 《中国临床药理学杂志》2024年第23期3477-3481,共5页田萍李金田李娟张毅梁建庆胡蓉文皓楠; 国家自然科学基金资助项目(82160872);甘肃省教育厅“双一流”科研基金资助项目(GSSYLXM-05)。; 氧化应激、炎症反应、细胞凋亡、自噬和衰老参与了慢性阻塞性肺疾病(COPD)的发病机制。Sirtuin 1(SIRT1)通过氧化应激、凋亡、炎症、自噬在COPD的发病和病情发展中发挥重要作用。本文旨在探讨SIRT1在COPD进展中的作用和机制及中医药防...; 关键词：中医药慢性阻塞性肺炎 Sirtuin 1 炎症凋亡氧化应激

miR-155 induces sepsis-associated damage to the intestinal mucosal barrier via sirtuin 1/nuclear factor-κB-mediated intestinal pyroptosis: 《Acta Biochimica et Biophysica Sinica》2024年第11期1618-1632,共15页Zhihua Li Yi Wang Weiwei Huang Xingyu Shi Tao Ma Xiangyou Yu; This work was supported by the grant from the National Natural Science Foundation of China(No.82160360).; Sepsis is a life-threatening state of organ dysfunction caused by systemic inflammation and a dysfunctional response to host infections that can induce severe intestinal mucosal damage.Pyroptosis is mediated by the ac...; 关键词：intestinal barrier dysfunction MIR-155 NF-KB PYROPTOSIS SEPSIS SIRT1

Glycyrrhizic acid alleviates lung injury in sepsis through SIRT1/HMGB1 pathway: 《BIOCELL》2024年第11期1613-1623,共11页BINGJIE LIN XIAOBO YING CHUANLING ZHANG GUOJUN ZHANG; supported by the Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project under Grant(No.2023ZL140).; Objectives:This study explores the protective effects of glycyrrhizic acid(GA)on sepsis-induced cellular damage and inﬂammation in acute lung injury(ALI),speciﬁcally through the modulation of the sirtuin 1(SIRT1)and h...; 关键词：Glycyrrhizin Acid SEPSIS sirtuin 1(SIRT1) high mobility group box 1(HMGB1)

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