funded by FEDER/Ministerio de Ciencia,Innovación y Universidades Agencia Estatal de Investigación/Project(PID2020-119729GB-100,REF/AEI/10.13039/501100011033)(to EP);a predoctoral fellowship from the Spanish Ministry of Universities(FPU)and Amigos de la Universidad de Navarra(to NSS);“Programa MRR Investigo 2023”(to MGB and MMD)。
Sirtuin 2 is a member of the sirtuin family nicotinamide adenine dinucleotide(NAD~+)-dependent deacetylases, known for its regulatory role in different processes, including inflammation. In this context, sirtuin 2 has...
Joint Funds for the Innovation of Science and Technology,Fujian Province,No.2021Y9106;Fujian Provincial Health Technology Project,No.2021GGA033;the Natural Science Foundation of Fujian Province,No.2024J011234.
BACKGROUND The NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome may play an important role in diabetic kidney disease(DKD).However,the exact link remains unclear.AIM To investigate the ...
Natural Science Basic Research Plan in Shannxi Province of China,the Intervention and Mechanism of Developmentalendotheliallocus-1 Regulating Macrophage Efferocytosis on Airway Inflammation in Chronic Obstructive Pulmonary Disease (No. 2020JQ-543);the Function and Mechanism of New Tumor Suppressor TSC22D2 in Cancer Glycometabolism (No. 2020JQ-927);Fundamental Research Funds for The Central University:the Role of TSC22D2-centered Protein Interaction Map in Cancer Glycometabolism and Cell Growth (No. xzy012019129)。
OBJECTIVE: To investigate the anti-liver cancer effect of 2-hydroxy-3-methyl anthraquinone(HMA) and the specific mechanism based on nicotinamide adenine dinucleotidedependent protein deacetylase sirtuin-1(SIRT1)/cellu...
This work was supported by the grant from the National Natural Science Foundation of China(No.82160360).
Sepsis is a life-threatening state of organ dysfunction caused by systemic inflammation and a dysfunctional response to host infections that can induce severe intestinal mucosal damage.Pyroptosis is mediated by the ac...
supported by the Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project under Grant(No.2023ZL140).
Objectives:This study explores the protective effects of glycyrrhizic acid(GA)on sepsis-induced cellular damage and inflammation in acute lung injury(ALI),specifically through the modulation of the sirtuin 1(SIRT1)and h...