血清幽门螺杆菌抗体联合胃蛋白酶原检测在胃癌和癌前病变筛查中的作用  

Role of Helicobacter pylori serum antibody combined with pepsinogen detection in screening of gastric cancer and precancerous lesions

作　　者：黎杨杨 林裕锋 陈冬玲 LI Yang-yang;LIN Yu-feng;CHEN Dong-ling(Department of Laboratory,Yangjiang People′s Hospital,Guangdong Province,Yangjiang 529500,China)

机构地区：[1]广东省阳江市人民医院检验科,广东阳江529500

出　　处：《中国当代医药》2020年第25期187-189,193,共4页China Modern Medicine

基　　金：广东省阳江市医疗卫生类科技计划项目(社发[2017]22)。

摘　　要：目的探讨血清幽门螺杆菌(Hp)抗体联合胃蛋白酶原(PG)检测在胃癌和癌前病变筛查中的作用。方法选取2019年6月~2020年1月我院收治的440例胃部疾病患者作为研究对象进行回顾性分析,将其纳入胃部疾病组,另选取同期我院的112例健康体检人员作为健康对照组。统计分析两组人员的Hp感染情况、血清PGⅠ、PGⅡ水平、PGR。结果胃部疾病各组(胃癌组、胃溃疡组、萎缩性胃炎组、浅表性胃炎组)与健康对照组的Hp阳性率、Hp阴性率比较,差异均无统计学意义(P>0.05)。胃溃疡组的血清PGⅠ水平高于健康对照组(P<0.05)。胃癌组、萎缩性胃炎组的血清PGⅠ水平均低于健康对照组(P<0.05)。胃癌组、胃溃疡组、萎缩性胃炎组的血清PGⅡ水平均高于健康对照组,PGR均低于健康对照组(P<0.05)。浅表性胃炎组与健康对照组的血清PGⅠ、PGⅡ、PGR比较,差异均无统计学意义(P>0.05)。胃癌组、胃溃疡组、萎缩性胃炎组、浅表性胃炎组、健康对照组Hp阳性和阴性人员的血清PGⅠ、PGⅡ、PGR比较,差异均无统计学意义(P>0.05)。结论在胃癌和癌前病变筛查中,检测Hp抗体和PG,具有积极的临床诊断价值,值得推广应用。Objective To investigate the role of serum Helicobacter pylori(Hp)antibody combined with pepsinogen(PG)detection in the screening of gastric cancer and precancerous lesions.Methods A total of 440 cases of patients with gastric diseases in our hospital From June 2019 to January 2020 were selected as gastric disease group,and 112 cases of healthy people in our hospital were selected as control group.The Hp infections,serum PGⅠ,PGⅡlevels and PGR of the two groups were statistically analyzed.Results Comparison of Hp positive rates and HP negative rates between gastric disease groups(gastric cancer group,gastric ulcer group,atrophic gastritis group,superficial gastritis group)and healthy control group showed no statistically significant differences(P>0.05).The serum PGⅠlevel of patients in the gastric ulcer group was higher than that of healthy control group(P<0.05).The serum PGⅠlevel of gastric cancer group and atrophic gastritis group was lower than that of the healthy control group(P<0.05).The serum PGⅡlevel of gastric cancer group,gastric ulcer group and atrophic gastritis group was higher than that of healthy control group,while the PGR level was lower than that of healthy control group(P<0.05).There were no significant differences in serum PGⅠ,PGⅡlevels and PGR between the superficial gastritis group and the healthy control group(P>0.05).There were no statistically significant differences in serum PGⅠ,PGⅡlevels and PGR between Hp positive and Hp negative subjects in gastric cancer group,gastric ulcer group,atrophic gastritis group,superficial gastritis group and healthy control group(P>0.05).Conclusion In the screening of gastric cancer and precancerous lesions,the detection of Hp antibody and PG has positive clinical diagnostic value and is worthy of promotion.

关 键 词：胃癌 癌前病变 血清幽门螺杆菌抗体 胃蛋白酶原 筛查 

分 类 号：R735.2[医药卫生—肿瘤]