主食摄入与全因死亡及心血管疾病发生风险的前瞻性队列研究  

Association Between Staple Food Consumption and Risk of All-cause Mortality and Cardiovascular Diseases:a Prospective Cohort Study

作　　者：夏雪 刘芳超[1] 杨学礼[1] 陈纪春[1] 李建新[1] 曹杰[1] 陈恕凤[1] 李莹[1] 赵连成[2] 鲁向锋[1] 黄建凤[1] 顾东风[1] XIA Xue;LIU Fangchao;YANG Xueli;CHEN Jichun;LI Jianxin;CAO Jie;CHEN Shufeng;LI Ying;ZHAO Liancheng;LU Xiangfeng;HUANG Jianfeng;GU Dongfeng(Key Laboratory of Cardiovascular Epidemiology&Department of Epidemiology,National Center for Cardiovascular Diseases and Fuwai Hospital,CAMS and PUMC,Beijing 102300,China)

机构地区：[1]中国医学科学院北京协和医学院,国家心血管病中心,阜外医院,心血管流行病学重点实验室,流行病研究部,北京市102300 [2]中国医学科学院北京协和医学院,国家心血管病中心,阜外医院,心血管流行病学重点实验室社区防治部,北京市102300

出　　处：《中国循环杂志》2020年第9期873-879,共7页Chinese Circulation Journal

基　　金：中国医学科学院医学与健康科技创新工程(2017-I2M-1-004,2019-I2M-2-003);国家重点研发计划(2017YFC0211700,2018YFC1311703)。

摘　　要：目的:以中国心血管疾病流行病多中心协作研究(ChinaMUCA)队列人群为基础,对我国南北方人群主食摄入与全因死亡及心血管疾病(CVD)发生风险间的关联进行探讨。方法:ChinaMUCA于1998年开展基线调查,收集主食摄入信息;于2007~2008年及2012~2015年随访,收集死亡及CVD结局资料。根据主食摄入情况将研究对象分为4组:<250 g/d组,(≥250~<400)g/d组,(≥400~<500)g/d组及≥500 g/d组。应用多因素Cox比例风险模型分别在南北方人群中分析主食摄入对全因死亡及CVD事件的影响。结果:共纳入9315例基线无重大慢性疾病个体。经过127059人年的随访,共发生全因死亡718例,CVD事件564例。多因素调整后,以(≥250~<400)g/d组为参照,南方地区<250 g/d组、(≥400~<500)g/d组及≥500 g/d组全因死亡HR(95%CI)分别为1.30(0.93~1.82)、1.08(0.84~1.38)和1.37(0.89~2.11);CVD事件HR(95%CI)分别为1.37(0.85~2.22)、0.74(0.49~1.10)和1.35(0.73~2.52),均呈现U型趋势。北方地区未见明显趋势,各组间差异无统计学意义。结论:主食摄入与全因死亡及CVD事件间无显著关联,在南方地区观察到的“U”型趋势及南北方地区间的潜在差异需大样本队列研究进一步验证。Objectives:To investigate the association between staple food consumption and risk of all-cause mortality and cardiovascular diseases(CVD)among the Chinese population.Methods:Data from participants taking part in the China Multi-Center Collaborative Study of Cardiovascular Epidemiology(ChinaMUCA)were analyzed.Information about staple food consumption was collected at the baseline survey in 1998.Incidence of all-cause mortality and CVD was obtained during two follow-up visits:2007-2008 and 2012-2015.Participants were divided into 4 groups according to baseline staple food consumption:<250 g/d group,(≥250-<400)g/d group,(≥400-<500)g/d group and≥500 g/d group.Multivariable Cox proportional hazards regression models were utilized to evaluate the association between staple food consumption and the risk of all-cause mortality and CVD in Southern and Northern populations,respectively.Results:A total of 9315 participants without major chronic diseases at baseline were included.During the 127059 person-years of follow-up,718 deaths and 564 CVD events were documented.There was a U-shaped association between staple food intake and all-cause mortality as well as CVD events among Southern Chinese.Compared with(≥250-<400)g/d group,the multivariable-adjusted HR(95%CI)for all-cause mortality was 1.30(0.93-1.82),1.08(0.84-1.38)and 1.37(0.89-2.11)for those with consumption of<250 g/d,(≥400-<500)g/d and≥500 g/d.The corresponding HR(95%CI)for CVD events was 1.37(0.85-2.22),0.74(0.49-1.10)and 1.35(0.73-2.52),respectively.No significant associations were found between staple food intake and all-cause mortality and CVD events among Northern Chinese.Conclusions:The current study suggests that staple food consumption is not associated with the risk of all-cause mortality and CVD events.Large-scale prospective cohort studies are needed to further validate the U-shaped association observed among Southern Chinese as well as the potential difference on the association of staple food consumption with the risk of all-cause mortalit

关 键 词：主食 全因死亡 心血管疾病 队列研究 

分 类 号：R541[医药卫生—心血管疾病]