MicroRNA在神经管畸形中的研究进展  

Research progress of microRNA in neural tube defects

作　　者：张娟[1] 杨丽红[1] 孙雨晴 王宇飞 刘志贞[1] 张霆[1] 解军[1] ZHANG Juan;YANG Lihong;SUN Yuqing;WANG Yufei;LIU Zhizhen;ZHANG Ting;XIE Jun(Department of Biochemistry and Molecular Biology,Shanxi Key Laboratory of Birth Defect and Cell Regeneration,Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学生物化学与分子生物学教研室,山西省出生缺陷与细胞再生重点实验室,太原030001

出　　处：《生命的化学》2020年第7期1049-1057,共9页Chemistry of Life

基　　金：山西省“1331工程”重点学科建设计划经费项目(1331KSC);山西省重点学科建设基金资助项目(FSKSC)。

摘　　要：微小RNA(microRNAs,miRNAs)是一类小的非编码RNA分子,参与基因表达的转录后调控,在细胞增殖、分化和器官发生过程中起着重要的调控作用。MiRNA的异常表达增加了多种疾病的发生风险,如神经管畸形(neural tube defects,NTDs),一种由于神经管关闭不完全而导致的严重先天性疾病。本文就miRNA与神经管发育、miRNA异常表达与NTDs发病机制的关系进行了综述,进一步探究了叶酸-miRNA的相互作用在疾病发病机制中的重要性,为疾病预防和临床治疗提供新的途径。MicroRNAs(miRNAs)are small non-coding RNA molecules involved in the post-transcriptional regulation of gene expression.MiRNAs play an important regulatory role in cell proliferation,differentiation and organogenesis.Abnormal expression of miRNAs is associated with increased risk of various diseases,such as neural tube defects(NTDs),which is a severe congenital disease caused by incomplete closure of neural tube.Here we briefly reviewed the relationship between miRNA and neural tube development,and abnormal miRNA expression and pathogenesis of NTDs.We further explored the importance of folate-miRNA interaction in the pathogenesis of disease,which provided a new approach for disease prevention and clinical treatment.

关 键 词：MIRNA 神经管畸形 发病机制 

分 类 号：R748[医药卫生—神经病学与精神病学]