小分子化合物诱导结直肠癌细胞死亡方式  

Small-molecule compounds targeting cell death signaling in colorectal cancer

作　　者：王景 汪哲 谭宁华[1] WANG Jing;WANG Zhe;TAN Ninghua(School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学中药学院,南京211198

出　　处：《生命的化学》2020年第7期1065-1072,共8页Chemistry of Life

基　　金：国家新药科技重大专项课题项目(2017ZX09309027)。

摘　　要：结直肠癌是世界上第三大常见癌症,其致死率在所有癌症中排第四位。亟需开发更多高效、安全的抗癌药物来改善结直肠癌患者的生存率。细胞死亡信号缺陷是结直肠癌的基本现象,越来越多能触发细胞死亡的小分子化合物被开发以发挥抗结直肠癌作用。基于此,本文围绕结直肠癌细胞的不同死亡方式以及诱导结直肠癌细胞死亡相关的小分子化合物的研究进展进行了综述,以期为结直肠癌治疗的药物研发提供参考。Colorectal cancer(CRC)is the third most common cancer in the world,and its mortality ranks the fourth in all cancers.It is urgent to develop more efficient and safe medicine to improve the survival rate of CRC patients.Defects in cell death signaling are a fundamental phenomenon in CRC.More and more smallmolecule compounds targeting cell death signaling have been developed for CRC treating.Therefore,the aim of this review is to illustrate the research progress of the different cell death modes and small-molecule compounds targeting cell death signaling in CRC,which will contribute to the research and development of anti-CRC medicine in the future.

关 键 词：结直肠癌 细胞死亡 小分子化合物 作用机制 

分 类 号：R735.34[医药卫生—肿瘤]