上皮-间质转化在恶性肿瘤发病和侵袭转移中的作用研究进展  

Research progress based on the role of epithelial-mesenchymal transition in the pathogenesis and invasion of malignant tumors

作　　者：潘琦璐 马礼兵 PAN Qilu;MA Libing(Department of Respiratory and Critical Care Medicine,Affiliated Hospital of Guilin Medical University,Institute of Respiratory Diseases,Guilin Medical University,Key Laboratory of Respiratory Diseases of Colleges and Universities Affiliated Education Department of Guangxi Zhuang Autonomous Region,Guilin 541001,China)

机构地区：[1]桂林医学院附属医院呼吸与危重症医学科,桂林医学院呼吸疾病研究所,广西壮族自治区教育厅高校呼吸疾病重点实验室,广西桂林541001

出　　处：《实用医学杂志》2020年第17期2443-2447,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金(编号:81760009,81560007);广西自然科学基金(编号:2015GXNSFAA139106)。

摘　　要：近年来,上皮-间质转化(EMT)在恶性肿瘤中的作用得到重视,而信号通路如TGF-β、Wnt、Notch以及Hedgehog(Hh)、黏蛋白(MUC)、微小核糖核酸(miRNA)、转录因子和生长因子等均参与了EMT形成过程。本研究将结合以上信号通路及相关因子介质对EMT在各系统恶性肿瘤发病和侵袭转移中的作用做简要综述。Recent years,the role of epithelial-mesenchymal transition(EMT)in malignant tumors has been valued.The related signaling pathways such as TGF-β、Wnt、Notch and Hedgehog(Hh),mucin(MUC),microRNA(miRNA),transcription factors,growth factors and so on,have been involved in the course of EMT.This paper will briefly review the role of EMT in the pathogenesis and invasion of various malignant tumors from the above signaling pathways and related factor media.

关 键 词：上皮间质转化 信号通路 恶性肿瘤 

分 类 号：R73[医药卫生—肿瘤]